SSEA1 Monoclonal Antibody (VIMC6), FITC

货号：MHCD1501

规格：0.5 mL

价格：3384

产品类型：抗体和染料

品牌：Thermo Fisher

物种：人

宿主：小鼠

抗体亚型：IgM

荧光染料：FITC

类型:	单抗	同型对照：
浓度：		用法：	Assay-Dependent(Flow)

产品详细信息Commonly used, FITC conjugates provide relatively high absorptivity, excellent fluorescence quantum yield, and good water solubility.靶标信息CD15 (Lewis X, Le(x); stage specific embryonic antigen-1, SSEA-1) is a trisacharide determinant (3-fucosyl-N-acetyllactosamine) expressed on several glycolipids, glycoproteins and proteoglycans of various cell types, e.g. granulocytes, mast cells, monocytes, macrophages, cells of gastric mucosa, nervous system or various tumour cells. There are several variants of Lewis x, such as sialyl-Lewis x or sulphated Lewis x. Cells with high surface expression of Le(x) antigen exhibit strong self-aggregation, based on calcium-dependent Le(x)-Le(x) interaction. This process is involved for example in embryo compaction or in autoaggregation of teratocarcinoma cells. Sialyl-Le(x) and its isomer sialyl-Le(a) are ligands of selectins. CD15 expression has been extensively used to confirm diagnosis of Hodgkin's disease.

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参考文献：

1.Nature chemical biologyNew IDH1 mutant inhibitors for treatment of acute myeloid leukemia."MHCD1501 was used in Flow cytometry/Cell sorting to providesproof of concept for the molecular and biological activity of novel allosteric inhibitors for targeting different mutant forms of IDH1 in leukemia."2.Science (New York, N.Y.)Distinct cellular interactions of secreted and transmembrane Ebola virus glycoproteins."MHCD1501 was used in flow cytometry to study the role of Ebola's glycoprotein in neutrophil and endothelial cell binding."3.TransfusionHuman placenta and chorion: potential additional sources of hematopoietic stem cells for transplantation."MHCD1501 was used in immunocytochemistry to discuss the use of umbilical cord blood as a source of transplantable hematopoietic stem cells."AuthorsBárcena A,Muench MO,Kapidzic M,Gormley M,Goldfien GA,Fisher SJ

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