SSEA1 Monoclonal Antibody (MC-480)

货号：41-1200

规格：100 µg

价格：4809

产品类型：流式抗体

品牌：Thermo Fisher

物种：人/小鼠

宿主：小鼠

抗体亚型：IgM

荧光染料：其它

类型:	单抗	同型对照：
浓度：	0.5 mg/mL	用法：	1-3 µg/mL (WB)；

靶标信息CD15 (Lewis X, Le(x); stage specific embryonic antigen-1, SSEA-1) is a trisacharide determinant (3-fucosyl-N-acetyllactosamine) expressed on several glycolipids, glycoproteins and proteoglycans of various cell types, e.g. granulocytes, mast cells, monocytes, macrophages, cells of gastric mucosa, nervous system or various tumour cells. There are several variants of Lewis x, such as sialyl-Lewis x or sulphated Lewis x. Cells with high surface expression of Le(x) antigen exhibit strong self-aggregation, based on calcium-dependent Le(x)-Le(x) interaction. This process is involved for example in embryo compaction or in autoaggregation of teratocarcinoma cells. Sialyl-Le(x) and its isomer sialyl-Le(a) are ligands of selectins. CD15 expression has been extensively used to confirm diagnosis of Hodgkin's disease.

数据

SSEA1 Antibody (41-1200) in ICC/IFIndirect immunofluorescent analysis of SHEFF4 human ES cells using Zymed Ms anti-SSEA-1 (Product # 41-1200). Image courtesy of Peter Andrews, Ph.D., University of Sheffield, Sheffield, UK.

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参考文献：

1.International journal of cancerComparative analysis of cell surface antigens expressed by cell lines derived from human germ cell tumours.2.Journal of stem cells & regenerative medicineMouse iPSC generated with porcine reprogramming factors as a model for studying the effects of non-silenced heterologous transgenes on pluripotency."41-1200 was used in Immunocytochemistry to evaluate the ability of transposon-based vectors with porcine pluripotency factors to reprogram mouse foetal fibroblasts to pluripotency."3.Cell cycle (Georgetown, Tex.)G1 checkpoint is compromised in mouse ESCs due to functional uncoupling of p53-p21Waf1 signaling."41-1200 was used in immunocytochemistry to determine the role of uncoupling of p53/p21-Waf1 signaling and G1 checkpoint disruption in mouse ESCs"4.Stem cells (Dayton, Ohio)Preimplantation human embryos and embryonic stem cells show comparable expression of stage-specific embryonic antigens.AuthorsHenderson JK,Draper JS,Baillie HS,Fishel S,Thomson JA,Moore H,Andrews PW5.Cell death discoveryResveratrol enhances pluripotency of mouse embryonic stem cells by activating AMPK/Ulk1 pathway."41-1200 was used in Flow cytometry/Cell sorting to study the effect of resveratrol on proliferation and pluripotency of mouse embryonic stem cells."AuthorsSuvorova II,Knyazeva AR,Petukhov AV,Aksenov ND,Pospelov VA

技术参数

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