Myc Tag Polyclonal Antibody

货号：A-21281

规格：100 µL

价格：6387

产品类型：标签抗体

品牌：Thermo Fisher

物种：其它

宿主：chicken

抗体亚型：其它

荧光染料：其它

类型:	单抗	同型对照：
浓度：	1 mg/mL	用法：	1 µg/mL (WB)；1-10 µg/mL(IHC)；Assay-dependent (ICC/IF)

靶标信息Myc is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. The encoded protein forms a heterodimer with the related transcription factor MAX. This complex binds to the E box DNA consensus sequence and regulates the transcription of specific target genes. Amplification of this gene is frequently observed in numerous human cancers. Translocations involving this gene are associated with Burkitt lymphoma and multiple myeloma in human patients. There is evidence to show that translation initiates both from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site, resulting in the production of two isoforms with distinct N-termini.

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参考文献：

1.Nature methodsMAZe: a tool for mosaic analysis of gene function in zebrafish."A-21281 was used in immunohistochemistry to create tools to help make inducible knockout zebrafish"2.The Journal of neuroscience : the official journal of the Society for NeuroscienceRe-Opening the Critical Window for Estrogen Therapy."A-21281 was used in immunohistochemistry - frozen section and western blot to determine the critical window for estrogen therapy"3.Proceedings of the National Academy of Sciences of the United States of AmericaEngineering a potent receptor superagonist or antagonist from a novel IL-6 family cytokine ligand."A-21281 was used in Immunocytochemistry to validate the CLCF1-CNTFR signaling axis as a therapeutic target and highlight an approach of engineering cytokine activity through a small number of mutations."4.mAbsAffinity maturation of antibodies by combinatorial codon mutagenesis versus error-prone PCR."A-21281 was used in Flow cytometry/Cell sorting to find that improved affinity for the full-length antibody did not always translate into enhanced binding to cell-surface expressed antigen or improved immune checkpoint blocking ability, suggesting that screening with full-length antibody or antigen-binding fragment formats might be advantageous and the subject of a future study."5.The Journal of cell biologyGenetically encoded live-cell sensor for tyrosinated microtubules."A-21281 was used in Flow cytometry/Cell sorting to describe a novel tyrosination sensor and its potential applications to study the dynamics of microtubules and their post-translational modification processes in living cells."

技术参数

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