Phospho-c-Myc (Thr58) Polyclonal Antibody

货号：PA5-36673

规格：100 µL

价格：5829

产品类型：免疫组化一抗

品牌：Thermo Fisher

物种：人

宿主：兔

抗体亚型：IgG3

荧光染料：其它

类型:	单抗	同型对照：
浓度：	1 mg/mL	用法：	1:1,000 (WB)；1:50-1:200(IHC (P))；1:50-1:200 (IP)

产品详细信息This antibody detects endogenous protein at a molecular weight of 49, 57 and 65 kDa.Purity is >95% by SDS-PAGE.靶标信息The c-Myc protein is a 62 kDa transcription factor that is encoded by the c-Myc gene on human chromosome 8q24. c-Myc is commonly activated in a variety of tumor cells and plays an important role in cellular proliferation, differentiation, apoptosis and cell cycle progression. The phosphorylation of c-Myc has been investigated and previous studies have suggested a functional association between phosphorylation at Thr58/Ser62 by glycogen synthase kinase 3, cyclin dependent kinase, ERK2 and C-Jun N terminal Kinase (JNK) in cell proliferation and cell cycle regulation. Studies have shown that c-Myc is essential for vasculogenesis and angiogenesis in tumor development, which distributes blood throughout the cells. The c-myc oncogene (p62 c-myc) is involved in the control of normal cellular proliferation and differentiation, and the deregulated expression of c-Myc induces apoptosis in different cell types. Antibodies against c-myc epitopes recognize overexpressed proteins containing Myc epitope tag fused to either amino- or carboxy-termini of targeted proteins. c-Myc-, N-Myc- and L-Myc-encoded proteins function in cell proliferation, differentiation and neoplastic disease. Amplification of the c-Myc gene has been found in several types of human tumors including lung, breast and colon carcinomas, while the N-Myc gene has been found amplified in neuroblastomas. Translocation of the c-myc locus on chromosome 8 to the immunoglobulin loci on chromosome 14 (heavy chain); 2 (delta light chain); or 22 (light chain) is described in Burkitts lymphoma and other B-cell lymphoproliferative conditions. An aberrant expression of the c-myc gene occurs in tumors of different origins such as colorectal, gastric, gallbladder, hepatic, mammary, ovarian, endometrial, head and neck, pulmonary, prostatic, thyroidal, oral, ocular, nasopharyngeal, endocrine, as well as hematopoietic neoplasms.

数据

Phospho-c-Myc (Thr58) Antibody (PA5-36673) in IHC (P)Immunohistochemistry analysis of Phospho-c-Myc (Thr58) in paraffin-embedded human breast carcinoma tissue. Samples were incubated with Phospho-c-Myc (Thr58) polyclonal antibody (Product # PA5-36673) at a dilution of 1:100.

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参考文献：

1.CancersN6-Isopentenyladenosine Inhibits Colorectal Cancer and Improves Sensitivity to 5-Fluorouracil-Targeting FBXW7 Tumor Suppressor."PA5-36673 was used in Western Blotting to provide novel insights into the molecular mechanism of N6-isopentenyladenosine, revealing its multi-targeting antitumor action, in vitro and in vivo."

技术参数

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