KLF4 Monoclonal Antibody (1E5)

货号：MA5-15672

规格：100 µL

价格：4805

产品类型：免疫组化一抗

品牌：Thermo Fisher

物种：人

宿主：小鼠

抗体亚型：IgG1

克隆号：1E5

荧光染料：其它

类型:	单抗	同型对照：
浓度：		用法：	1:500-1:2,000 (WB)；1:200-1:1,000(IHC)；1:10,000 (ELISA)

产品详细信息MA5-15672 targets KLF4 in IHC and WB applications and shows reactivity with Human samples.The MA5-15672 immunogen is purified recombinant fragment of human KLF4 (Amino Acid: 2-470) expressed in E. Coli.MA5-15672 detects KLF4 which has a predicted molecular weight of approximately 55kDa.靶标信息Kruppel like factor 4 (KLF4) protein is encoded by the KLF4 gene located on chromosome 9 in humans. It is also known as gut-enriched Kruppel-like factor (GKLF) or epithelial zinc-finger protein (EZF) and belongs to a family of conserved Kruppel-like factor family of DNA binding zinc finger transcription factors. KLF4 exerts its functional relevance across varied cellular pathways. As one of the four Yamanaka factors, it plays a key role in reprogramming differentiated cells into pluripotent stem cells. Most studies have focused on its specific role in endothelial cell signaling, adipogenesis, differentiation, embryogenesis and cell cycle control. Localization plays an important role in the biological significance of this protein wherein nuclear localization is associated with its function as an oncogene and cytosolic localization with tumor suppression specific effect.

数据

KLF4 Antibody (MA5-15672) in IHCImmunohistochemical analysis of paraffin-embedded lung cancer tissues (left) and human rectum tissues (right) using KLF4 monoclonal antibody (Product # MA5-15672) followed with DAB staining.

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参考文献：

1.Stem cells internationalGenes Involved in the Transcriptional Regulation of Pluripotency Are Expressed in Malignant Tumors of the Uterine Cervix and Can Induce Tumorigenic Capacity in a Nontumorigenic Cell Line."Published figure using KLF4 monoclonal antibody (Product # MA5-15672) in Western Blot"2.International journal of molecular sciencesIntratumoral Distribution of Lactate and the Monocarboxylate Transporters 1 and 4 in Human Glioblastoma Multiforme and Their Relationships to Tumor Progression-Associated Markers."Published figure using KLF4 monoclonal antibody (Product # MA5-15672) in Immunocytochemistry"3.OncotargetDormant glioblastoma cells acquire stem cell characteristics and are differentially affected by Temozolomide and AT101 treatment."Published figure using KLF4 monoclonal antibody (Product # MA5-15672) in Immunocytochemistry"4.International journal of molecular sciencesIntratumoral Distribution of Lactate and the Monocarboxylate Transporters 1 and 4 in Human Glioblastoma Multiforme and Their Relationships to Tumor Progression-Associated Markers."Published figure using KLF4 monoclonal antibody (Product # MA5-15672) in Immunocytochemistry"5.OncotargetDormant glioblastoma cells acquire stem cell characteristics and are differentially affected by Temozolomide and AT101 treatment."Published figure using KLF4 monoclonal antibody (Product # MA5-15672) in Immunocytochemistry"

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