C17orf96 Polyclonal Antibody

货号：PA5-63319

规格：100 µL

价格：5548

产品类型：免疫组化一抗

品牌：Thermo Fisher

物种：人

宿主：兔

抗体亚型：IgG

荧光染料：其它

类型:	单抗	同型对照：
浓度：		用法：	1:500-1:1,000 (IHC);0.25-2 µg/mL (ICC/IF)

产品详细信息Immunogen sequence: NCFPCPPALV VGEDGDLKPA SSLRLQGDSKHighest antigen sequence identity to the following orthologs: Mouse - 83%, Rat - 83%.靶标信息Elongin BC and Polycomb repressive complex 2-associated protein (EPOP) also know as C17ORF96 is a scaffold protein that serves as a bridging partner between the PRC2/EED-EZH2 complex and the elongin BC complex. It is required to fine tune the transcriptional status of polycomb group (PcG) target genes in embryonic stem cells (ESCs). C17ORF96 also plays a key role in genomic regions that display both active and repressive chromatin properties in pluripotent stem cells by sustaining low level expression of PcG target genes. It acts by recruiting the elongin BC complex, thereby restricting excessive activity of the PRC2/EED-EZH2 complex. C17ORF96 also has interacts with USP7 and promotes deubiquitination of H2B at promoter sites.

数据

C17orf96 Antibody (PA5-63319) in ICC/IFImmunofluorescent staining of C17orf96 in human cell line Hep G2 using a C17orf96 Polyclonal Antibody (Product # PA5-63319) shows localization to nucleoplasm and cytosol.

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