GLP-1 Recombinant Rabbit Monoclonal Antibody (24H1L3)

货号：701296

规格：100 µg

价格：4809

产品类型：抗体和染料

品牌：Thermo Fisher

物种：人/小鼠

宿主：兔

抗体亚型：IgG

克隆号：24H1L3

荧光染料：其它

类型:	单抗	同型对照：
浓度：	0.5 mg/mL	用法：	2-3 µg/mL(WB)

产品详细信息This antibody is predicted to react with rat, non-human primate and rabbit based on sequence homology.Intact IgG appears on a non-reducing gel as ~150 kDa band and upon reduction generating a ~25 kDa light chain band and a ~50 kDa heavy chain.Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.靶标信息GCG is also known as GLP1, or Glucagon. Glucagon is a 29-amino acid pancreatic hormone that counteracts the glucose-lowering action of insulin by stimulating glycogenolysis and gluconeogenesis.It is mapped to 2q36-2q37. GLP1, also known as 7-37 for the codons of the preproglucagon molecule which encode it, renders pancreatic beta-cells 'glucose-competent' and may be useful in the treatment of noninsulin-dependent diabetes mellitus. Also, GLP1 is a potent insulin secretagogue.It plays a major role in the enteroinsular axis, accounting, for example, for the finding that plasma insulin levels accompanying oral intake of glucose are greater than those observed when glucose is given intravenously.

数据

GLP-1 Antibody (701296) in WBWestern blot analysis of Glucagon in whole cell extracts from mouse small intestine using a Glucagon recombinant rabbit monoclonal antibody (Product # 701296) at a dilution of 2 µg/mL. Samples were detected using chemiluminescence (ECL). Results show a band at ~21kDa.

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