Glucagon Polyclonal Antibody

货号：PA5-83353

规格：100 µL

价格：6049

产品类型：抗体和染料

品牌：Thermo Fisher

物种：人

宿主：兔

抗体亚型：IgG

荧光染料：其它

类型:	单抗	同型对照：
浓度：	0.2 mg/mL	用法：	1:500-1:1,000(IHC (P))

产品详细信息Immunogen sequence: ERHAEGTFTS DVSSYLEGQA AKEFIAWLVK GRGRRDFPEE VAIVEELGRR HADGSFSDEM NTILDNLAAR DFINWLIQ靶标信息Glucagon is a 29-residue polypeptide hormone (MW 3482), produced in the pancreas. A related hormone, enteroglucagon (or oxyntomodulin), which is produced in the mucosa of the small and large intestine, consists of the 29 amino acid sequence of pancreatic glucagon extended by 8 additional residues at the C-terminus. The biological activities of pancreatic glucagon include glycogenolysis, lipolysis, gluconeogenesis, and ketogensis, which are antagonistic effects to those of insulin action, thus leading to increased blood glucose levels. Immunocytochemical studies have revealed the presence of pancreatic glucagon inside the A or alpha cells, which constitute 15-20% of the islet cell population. These cells are located preferentially at the periphery of the human pancreatic islets. Pathological manifestations of the glucagon-type peptide residue almost exclusively with the exsistence of tumors or glucagonomas, as no states of glucagon-cell deficiency or hyperplasia have been identified. Glucagon-specific antibodies would prove useful as a cell and tumor markers applying immunohistochemical techniques, and as an analytical tool in qualification of the hormone.

数据

Glucagon Antibody (PA5-83353) in IHCImmunohistochemical analysis of Glucagon in human pancreas and liver tissues using a Glucagon polyclonal antibody (Product # PA5-83353). Corresponding RNA-seq data are presented for the same tissues.

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