TNFR1 (Soluble) Human ELISA Kit ELISA试剂盒,TNFR1 (Soluble) Human ELISA Kit/人TNFR1 (Soluble) ELISA试剂盒-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

TNFR1 (Soluble) Human ELISA Kit ELISA试剂盒,TNFR1 (Soluble) Human ELISA Kit/人TNFR1 (Soluble) ELISA试剂盒

2024-10-23

TNFR1 (Soluble) Human ELISA Kit/人TNFR1 (Soluble) ELISA试剂盒

货号：KAC1761

规格：96 tests

价格：7030

产品类型：Platinum ELISA

品牌：Thermo Fisher

物种：人

宿主：其它

抗体亚型：其它

荧光染料：其它

灵敏度	50 pg/mL
检测范围	1-47 ng/mL
样本类型/体积	上清液 50 μL 血清 50μL 血浆 50μL
操作时间	1 hr 20 min
测试时间	1 hr 15 min
Homogenous (no wash)	No
批间变异系数（CV）	7.3%
批内变异系数（CV）	4.6%
仪器设备	Colorimetric Microplate Reader 酶标仪
规格	96 Tests
组份	- 预包被96孔板 - 标准品 - 标准稀释液 - 孵育缓冲液 - HRP-共轭检测抗体 - 洗涤液 - 显色剂 - 终止液 - 对照
储存温度	2-8℃
Protein name	TNFR1
Protein aliases	CD120a, p55, p60, TBPI, TNF-R1, TNF-RI, TNFR-I, tumor necrosis factor binding protein 1, Tumor necrosis factor receptor 1, tumor necrosis factor receptor 1A isoform beta, Tumor necrosis factor receptor superfamily member 1A, membrane form, tumor necrosis factor receptor superfamily, member 1A, tumor necrosis factor receptor type 1, Tumor necrosis factor receptor type I, tumor necrosis factor-alpha receptor, Tumor necrosis factor-binding protein 1
物种（Tested）	人
试剂盒类型	Sandwich ELISA Kit
标记（染料）	HRP
检测抗体偶联物	HRP
Gene aliases	CD120a, FPF, MS5, p55, p55-R, p60, TBP1, TNF-R, TNF-R-I, TNF-R55, TNFAR, TNFR1, TNFR1-d2, TNFR55, TNFR60, TNFRSF1A
Gene ID	(Human) 7132
Gene symbol	TNFRSF1A
UniProt ID	(Human) P19438

The Human Tumor Necrosis Factor Receptor 1 (Hu TNFR1) ELISA quantitates Hu TNFR1 in human serum, plasma, buffered solution, or cell culture medium. The assay will exclusively recognize both natural and recombinant Hu TNFR1.人肿瘤坏死因子受体1（人TNFR1）ELISA定量分析人血清，血浆，缓冲液或细胞培养基中的人TNFR1。该检测试剂盒将专门识别天然和重组人TNFR1。Principle of the method 方法原理The Human TNFR1 solid-phase sandwich ELISA (enzyme-linked immunosorbent assay) is designed to measure the amount of the target bound between a matched antibody pair. A target-specific antibody has been pre-coated in the wells of the supplied microplate. Samples, standards, or controls are then added into these wells and bind to the immobilized (capture) antibody. The sandwich is formed by the addition of the second (detector) antibody, a substrate solution is added that reacts with the enzyme-antibody-target complex to produce measurable signal. The intensity of this signal is directly proportional to the concentration of target present in the original specimen.人TNFR1固相夹心ELISA（酶联免疫吸附测定）设计用于测量匹配的抗体对之间结合的靶标量。已在提供的微孔板的孔中预包被了靶标特异性抗体。然后将样品，标准液或质控品添加到这些孔中，并与固定的（捕获）抗体结合。通过添加第二（检测）抗体形成三明治，添加底物溶液，该底物溶液与酶-抗体-靶标复合物反应以产生可测量的信号。该信号的强度与原始样品中存在的靶标浓度成正比。Rigorous validation 严格验证Each manufactured lot of this ELISA kit is quality tested for criteria such as sensitivity, specificity, precision, and lot-to-lot consistency. See manual for more information on validation.此ELISA试剂盒的每个制造批次均经过质量测试，其标准包括敏感性，特异性，精密度和批次间一致性。有关验证的更多信息，请参见手册。Target information 靶标信息TNFR1 (Tumor necrosis factor receptor 1) belongs to the tumor necrosis factor superfamily, and is one of the major TNF-alpha receptors. TNFR1 plays an important role in mediating, in cytokine mediated signaling, positive regulation of the NF-Kb pathway, positive regulation of angiogenesis, and negative regulation of gene expression. The extracellular domain of TNFR1 is also released into the circulatory system as soluble TNFR1 (sTNFR1). In humans, the TNFR1 gene is located on chromosome 12. Anti-apoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with TNFR1, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of TNFR1 were found to be associated with the autosomal dominant periodic fever syndrome, and the impaired receptor clearance is thought to be a mechanism of the disease.TNFR1（肿瘤坏死因子受体1）属于肿瘤坏死因子超家族，是主要的TNF-α受体之一。 TNFR1介导细胞因子介导的信号传导，NF-Kb途径的正调控，血管生成的正调控和基因表达的负调控中起着重要的作用。 TNFR1的细胞外结构域也以可溶性TNFR1（sTNFR1）的形式释放到循环系统中。在人类中，TNFR1基因位于12号染色体上。抗凋亡蛋白BCL2相关的致癌基因4（BAG4 / SODD）和衔接蛋白TRADD和TRAF2已显示与TNFR1相互作用，因此在介导的信号转导中起调节作用由受体。发现TNFR1胞外域的种系突变与常染色体显性周期性发热综合征有关，并且受体清除能力受损被认为是该疾病的一种机制。For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.仅供研究使用。不用于诊断过程。未经明确授权不得转售。

数据：

TNFR1 (Soluble) Human ELISA KitRepresentative lot to lot consistency data using 2 human controls for Human TNF Receptor I ELISA

技术参数

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TNFR1 (Soluble) Human ELISA Kit ELISA试剂盒,TNFR1 (Soluble) Human ELISA Kit/人TNFR1 (Soluble) ELISA试剂盒

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