Mouse IL-10 ELISA Standard Recombinant Protein,Mouse IL-10 ELISA Standard Recombinant Protein/小鼠IL-10 ELISA标准重组蛋白

2024-10-23

Mouse IL-10 ELISA Standard Recombinant Protein/小鼠IL-10 ELISA标准重组蛋白

货号:29-8101-65

规格:4 pack

价格:1454

产品类型:标准品和抗体对

品牌:Thermo Fisher

物种:小鼠

宿主:其它

抗体亚型:其它

荧光染料:其它

应用

Assay-Dependent(Ctrl);Assay-Dependent(ELISA)

种属反应

Mouse

宿主/亚型

E.coli

分类

Recombinant

类型

Protein

偶联物

Unconjugated

形式

Lyophilized

纯化类型

Affinity chromatography

内含物

no preservative

保存条件

4° C

产品详细信息Description: Mouse IL-10 is an ~18 kDa cytokine, also known as Cytokine Synthesis Inhibitory Factor (CSIF). In the mouse, Th2 cells, B1 cells and keratinocytes are the major cell subsets that produce IL-10. IL-10 inhibits synthesis of Th1 cytokines and proliferation of T cells, and acts as a costimulatory signal for mast cells, developing thymocytes and the Th2 response.Applications Reported: The Mouse IL-10 Lyophilized Standard is intended to be used as a standard for the Mouse IL-10 Ready-Set-Go! ELISA kit (cat. 88-7105). Typically the standard is run in a series of 7 doubling dilutions from the 'top' standard. Please refer to the Certificate of Analysis included with each ELISA set for instructions on the proper reconstitution and dilution of the lyophilized standard.Note: These are single-use vials. Use one time within 4 hours of reconstitution and discard. Reconstitute and dilute as suggested in the Certificate of Analysis or recovery may not be accurate.Applications Tested: The Mouse IL-10 Lyophilized Standard has been calibrated and tested in the Mouse IL-10 Ready-Set-Go! ELISA kit (cat. 88-7105).Source: E. coli expressed amino acids Ser 19-Ser 178 of mature mouse IL-10 accession # NM_010548 with a Cys149tyr substitution.靶标信息Interleukin 10 (IL-10, CSIF) is an anti-inflammatory cytokine mainly produced by macrophages and Th2 cells. IL-10 is an 18.6 kDa protein of 160 amino acid residues that shares over 80% sequence homology with the Epstein-Barr Virus protein (BCRFI). The reported biological activities of IL-10, which maybe interrelated, include inhibition of macrophage-mediated cytokine synthesis, suppression of the delayed-type hyper-sensitivity response, and stimulation of the Th2 cell response which results in elevated antibody production. IL-10 functions by inhibiting pro-inflammatory cytokines made by macrophages and regulatory T cells including IFN-gamma, TNF-alpha, IL-2, and IL-3, IL-4, and GM-CSF. IL-10 is also known to suppress antigen presentation on antigen presenting cells, enhances B cell survival, proliferation, and antibody production. IL-10 can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. While human IL-10 can act on murine cells, murine IL-10 cannot act on human cells. Binds to a retinoid X receptor (RXR) responsive element from the cellular retinol-binding protein II promoter (CRBPII-RXRE). IL-10 inhibits the 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element. Knockout studies in mice suggest the function of this cytokine as an essential immunoregulator in the intestinal tract.
技术参数
© bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪是专业的授权总代理区域代理经销平台。
© 如需询价,请加客服QQ:1749072012 、客服微信:jinshanbio,或发送邮件到1749072012@qq.com
© 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务,数据资源基于CC协议。
© 本文地址:https://gibcohyclone.cn/thread-45058.htm
产品询价需求提交
返回
扫码添加客服微信,咨询产品报价