Mouse IL-10 ELISA Standard Recombinant Protein/小鼠IL-10 ELISA标准重组蛋白
货号:29-8101-65
规格:4 pack
价格:1454
产品类型:标准品和抗体对
品牌:Thermo Fisher
物种:小鼠
宿主:其它
抗体亚型:其它
荧光染料:其它
应用 | Assay-Dependent(Ctrl);Assay-Dependent(ELISA) |
种属反应 | Mouse |
宿主/亚型 | E.coli |
分类 | Recombinant |
类型 | Protein |
偶联物 | Unconjugated |
形式 | Lyophilized |
纯化类型 | Affinity chromatography |
内含物 | no preservative |
保存条件 | 4° C |
产品详细信息Description: Mouse IL-10 is an ~18 kDa cytokine, also known as Cytokine Synthesis Inhibitory Factor (CSIF). In the mouse, Th2 cells, B1 cells and keratinocytes are the major cell subsets that produce IL-10. IL-10 inhibits synthesis of Th1 cytokines and proliferation of T cells, and acts as a costimulatory signal for mast cells, developing thymocytes and the Th2 response.Applications Reported: The Mouse IL-10 Lyophilized Standard is intended to be used as a standard for the Mouse IL-10 Ready-Set-Go! ELISA kit (cat. 88-7105). Typically the standard is run in a series of 7 doubling dilutions from the 'top' standard. Please refer to the Certificate of Analysis included with each ELISA set for instructions on the proper reconstitution and dilution of the lyophilized standard.Note: These are single-use vials. Use one time within 4 hours of reconstitution and discard. Reconstitute and dilute as suggested in the Certificate of Analysis or recovery may not be accurate.Applications Tested: The Mouse IL-10 Lyophilized Standard has been calibrated and tested in the Mouse IL-10 Ready-Set-Go! ELISA kit (cat. 88-7105).Source: E. coli expressed amino acids Ser 19-Ser 178 of mature mouse IL-10 accession # NM_010548 with a Cys149tyr substitution.靶标信息Interleukin 10 (IL-10, CSIF) is an anti-inflammatory cytokine mainly produced by macrophages and Th2 cells. IL-10 is an 18.6 kDa protein of 160 amino acid residues that shares over 80% sequence homology with the Epstein-Barr Virus protein (BCRFI). The reported biological activities of IL-10, which maybe interrelated, include inhibition of macrophage-mediated cytokine synthesis, suppression of the delayed-type hyper-sensitivity response, and stimulation of the Th2 cell response which results in elevated antibody production. IL-10 functions by inhibiting pro-inflammatory cytokines made by macrophages and regulatory T cells including IFN-gamma, TNF-alpha, IL-2, and IL-3, IL-4, and GM-CSF. IL-10 is also known to suppress antigen presentation on antigen presenting cells, enhances B cell survival, proliferation, and antibody production. IL-10 can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. While human IL-10 can act on murine cells, murine IL-10 cannot act on human cells. Binds to a retinoid X receptor (RXR) responsive element from the cellular retinol-binding protein II promoter (CRBPII-RXRE). IL-10 inhibits the 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element. Knockout studies in mice suggest the function of this cytokine as an essential immunoregulator in the intestinal tract.
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