Mouse IL-6 ELISA Standard Recombinant Protein,Mouse IL-6 ELISA Standard Recombinant Protein/小鼠IL-6 ELISA标准重组蛋白

2024-10-23

Mouse IL-6 ELISA Standard Recombinant Protein/小鼠IL-6 ELISA标准重组蛋白

货号:29-8061-65

规格:4 pack

价格:1454

产品类型:标准品和抗体对

品牌:Thermo Fisher

物种:小鼠

宿主:其它

抗体亚型:其它

荧光染料:其它

应用

Assay-Dependent(Ctrl);Assay-Dependent(ELISA)

种属反应

Mouse

宿主/亚型

E.coli

分类

Recombinant

类型

Protein

偶联物

Unconjugated

形式

Lyophilized

纯化类型

Affinity chromatography

内含物

no preservative

保存条件

4° C

产品详细信息Description: Mouse IL-6 (also known as B Cell Stimulating Factor, BCSF, and BSF-2) is a ~21-28 kDa factor produced by a variety of cell types, including monocytes, fibroblasts and endothelial cells. Upon stimulation, macrophages, T, B, mast, and glial cells, eosinophils, keratinocytes and granulocytes also secrete IL-6. This pleiotrophic cytokine influences the antigen-specific immune response, inflammatory response, and the development of neurons, and is a major mediator of the acute phase reaction.Applications Reported: Mouse IL-6 Lyophilized Standard has been reported for use in the Mouse IL-6 ELISA Ready-SET-Go! Set (cat. 88-7064).Applications Tested: The intended use of the Mouse IL-6 Lyophilized Standard is as a standard for Mouse IL-6 ELISA (cat. 88-7064). Typically the standard is run in a series of 7 doubling dilutions from the 'top' standard. Please refer to the Certificate of Analysis included with each ELISA set for instructions on the proper reconstitution and dilution of the lyophilized standard.Note: These are single-use vials. Use one time within 4 hours of reconstitution and discard. Reconstitute and dilute as suggested in the Certificate of Analysis or recovery may not be accurate.Source: E. coli expressed amino acids Phe 25-Thre 211 of mature mouse IL-6 accession # MMINTL6.靶标信息Interleukin 6 (IL-6) is a multifunctional 26 kD protein originally discovered in the medium of RNA-stimulated fibroblastoid cells. IL-6 appears to be directly involved in the responses that occur after infection and cellular injury, and it may prove to be important as IL-1 and TNF-a in regulating the acute phase response. IL-6 is reported to be produced by fibroblasts, activated T cells, activated monocytes or macrophages and endothelial cells. IL-6 acts upon a variety of cells including myeloidprogenitor cells, T cells, B cells, and hepatocytes. In addition, IL-6 appears to interact with IL-2 in the proliferation of T lymphocytes. IL-6 potentiates the proliferative effect of IL-3 on multipotential hematopoietic progenitors. IL-6 plays a critical role in B-cell differentiation to plasma cells and is a potent growth factor for plasmacytoma and myeloma. IL-6 is a very useful culture supplement for the generation of a high number of antibody-producing hybridomas. Primarily produced at sites of acute and chronic inflammation, IL-6 is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of IL-6 is implicated in a wide variety of inflammation-associated disease states including diabetes mellitus and systemic juvenile rheumatoid arthritis.
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