Human IL-1 beta ELISA Standard Recombinant Protein/人IL-1 β ELISA标准重组蛋白

货号：29-8018-65

规格：4 pack

价格：1454

产品类型：标准品和抗体对

品牌：Thermo Fisher

物种：人

宿主：其它

抗体亚型：其它

荧光染料：其它

应用	Assay-Dependent（Ctrl）；Assay-Dependent（ELISA）
种属反应	Human
宿主/亚型	E.coli
分类	Recombinant
类型	Protein
偶联物	Unconjugated
形式	Lyophilized
纯化类型	Affinity chromatography
内含物	no preservative
保存条件	4° C

产品详细信息Description: Human IL-1 beta, also called lymphocyte activating factor (LAF), endogenous pyrogen (EP), leucocyte endogenous mediator (LEM), mononuclear cell factor (MCF), is produced by a wide variety of cells, including macrophages, dendritic cells, T cells and B cells. IL-1 beta is mostly released and has only 20% amino acid homology with IL-1 alpha. The immune regulatory role of IL-1 beta is exerted on a wide range of cells including lymphocytes, epithelial cells and fibroblasts. In vivo, itinduces hypotension, fever, and acute phase response.Applications Reported: Human IL-1 beta ELISA Lyophilized Standard has been reported for use in the Human IL-1 beta Ready-Set-Go! ELISA kit (cat. 88-7261).Applications Tested: The Human IL-1 beta ELISA Lyophilized Standard is intended to be used as a standard for the Human IL-1 beta Ready-Set-Go! ELISA kit (cat. 88-7261). Typically the standard is run in a series of 7 doubling dilutions from the 'top' standard. Please refer to the Certificate of Analysis included with each ELISA set for instructions on the proper reconstitution and dilution of the lyophilized standard.Note: These are single-use vials. Use one time within 4 hours of reconstitution and discard. Reconstitute and dilute as suggested in the Certificate of Analysis or recovery may not be accurate.Source: E. coli expressed amino acids Ala117-Ser269 of human IL-1 beta accession # NM_000576.靶标信息Interleukin-1 beta (IL-1 beta) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 beta is synthesized in response to inflammatory stimuli as a 31 kDa inactive pro-form that accumulates in the cytosol. Cleavage of pro-IL-1 beta into the active 17 kDa protein requires the activation of inflammasomes, which are multi-protein complexes that respond to pathogens, stress conditions, and other danger signals. Inflammasome activation triggers the processing of the caspase-1 precursor into its active form, which in turn cleaves pro-IL-1 beta. IL-1 beta lacks a signal sequence peptide for classical ER/Golgi pathway and is secreted alongside caspase-1 via an alternate and incompletely understood mechanism. Although IL-1 beta is most often secreted in its active form, secretion of the uncleaved protein may be detectable under some biological conditions. IL-1 beta signals through two receptors, IL-1RI and IL-1RII, both of which are shared with IL-1 alpha. IL-1 beta activity can be moderated by IL-1 Receptor Antagonist (IL-1RA), a protein produced by many cell types that blocks receptor binding through competitive inhibition. IL-1 beta play an important role in innate host defense by triggering the production of other proinflammatory cytokines in target cells and initiating acute-phase responses to infection and injury. Elevated levels of IL-1 beta have been associated with many chronic inflammatory conditions IL-1 beta neutralizing antibodies potential therapeutic value.

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