Granzyme B Monoclonal Antibody (eBioLUEE), Biotin, eBioscience/颗粒酶B单克隆抗体（eBioLUEE），生物素，eBioscience

货号：13-8821-81

规格：50 µg

价格：2696

产品类型：抗体和ELISA

品牌：eBioscience

类型:	单抗	同型对照：	Rat IgG2a kappa Isotype Control (eBR2a), Biotin, eBioscience
浓度：	0.5 mg/mL	用法：	0.5-2 µg/mL（ELISA)

产品详细信息Description: The eBioLUEE antibody reacts with mouse Granzyme B (GrB) which is a member of the granzyme serine protease family. GrB is found in the granules of cytotoxic T cells and NK cells. Granzyme B has also been described as CGL1 (cathepsin G-like-1), a serine protease expressed only in cytotoxic T-lymphocytes after cell activation. GrB has been called CTLA-1 (cytotoxic T lymphocyte-associated serine esterase 1) based on identification of mRNA in various cytotoxic T cells, but not observedin non-cytotoxic lymphoid cells. GrB is crucial for the rapid induction of target cell death by apoptosis, induced by interaction with cytotoxic T cells. The receptor involved has been identified as mannose 6-phosphate receptor. This receptor functions as a death receptor for granzyme B during cytotoxic T cell-induced apoptosis.Applications Reported: This eBioLUEE antibody has been reported for use in ELISA.Applications Tested: The eBioLUEE antibody has been tested as the detection antibody in a sandwich ELISA for analysis of mouse granzyme B in combination with the purified 16G6 (cat. 14-8822) antibody for capture and recombinant mouse granzyme B as the standard. A suitable range of concentrations of this antibody for ELISA detection is 0.5-2 µg/mL.Filtration: 0.2 µm post-manufacturing filtered.靶标信息Granzyme B is a member of the granzyme serine protease family, and is found in the granules of cytotoxic T cells and NK cells. Granzyme B has been described as CGL1 (cathepsin G-like-1), a serine protease expressed only in cytotoxic T-lymphocytes after cell activation, and CTLA-1 (cytotoxic T lymphocyte-associated serine esterase 1) based on identification of mRNA in various cytotoxic T cells, but not observed in non-cytotoxic lymphoid cells. Granzyme B is crucial for the rapid induction of target cell death by apoptosis, induced by interaction with cytotoxic T cells. The receptor involved in this process has been identified as mannose 6-phosphate receptor which functions as a death receptor for Granzyme B during cytotoxic T cell-induced apoptosis. Granzyme B enters target cells to cleave caspase-3 and initiate the caspase cascade leading to DNA fragmentation and apoptosis. Granzyme B can also act through a mitochondrial apoptosis pathway by cleaving the Bid protein. Granzymes are neutral serine proteases, which are stored in specialized lytic granules of cytotoxic T lymphocytes (CTLs) and in natural killer (NK) cells. A number of granzymes (A to G) have been isolated and cloned from mouse CTLs and NK cells, however in man, fewer have been cloned and identified.

数据

Granzyme B Antibody (13-8821-81) in ELISAStandard curve of mouse Granzyme B ELISA. R.

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