IL-23 Human ELISA Kit ELISA试剂盒,IL-23 Human ELISA Kit/人IL-23 ELISA试剂盒-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

IL-23 Human ELISA Kit ELISA试剂盒,IL-23 Human ELISA Kit/人IL-23 ELISA试剂盒

2024-10-23

IL-23 Human ELISA Kit/人IL-23 ELISA试剂盒

货号：BMS2023-3,BMS2023-3TEN

规格：96 Tests,10X96 Tests

价格：1,35475

产品类型：Platinum ELISA

品牌：Thermo Fisher

物种：人

宿主：其它

抗体亚型：其它

荧光染料：其它

灵敏度	4.0 pg/mL
检测范围	15.6-2,000 pg/mL
样本类型/体积	血清 50 μL 血浆 50 μL 上清液 50 μL
操作时间	1 hr 20 min
测试时间	3 hr 45 min
Homogenous (no wash)	No
批间变异系数（CV）	6.3%
批内变异系数（CV）	5.9%
仪器设备	Colorimetric Microplate Reader 酶标仪
规格	10 x 96 tests
组份	- 预包被96孔板 - 标准品 - 样品稀释液 - 测定稀释浓缩液 - 生物素化检测抗体 - SAV-HRP - 洗涤液 - 显色剂 - 终止液 - 胶板盖
储存温度	2-8℃
Protein name	IL-23
Protein aliases	IL-23 subunit alpha, IL-23-A, Interleukin-23 subunit p19, IL-23p19, interleukin 23 p19 subunit, interleukin 23, alpha subunit p19, Interleukin-23 subunit alpha, interleukin-six, G-CSF related factor, JKA3 induced upon T-cell activation
物种（Tested）	人
试剂盒类型	Sandwich ELISA Kit
标记（染料）	HRP
检测抗体偶联物	Biotin
Gene aliases	IL-23, IL-23A, IL23A, IL23P19, P19, SGRF, UNQ2498/PRO5798
Gene ID	(Human) 51561
Gene symbol	IL23A
UniProt ID	(Human) Q9NPF7

The Human Interleukin-23 (Hu IL-23) ELISA quantitates Hu IL-23 in human serum, plasma, buffered solution, or cell culture medium. The assay will exclusively recognize both natural and recombinant Hu IL-23.人白介素23（人IL-23）ELISA可以定量人血清，血浆，缓冲液或细胞培养基中的人IL-23。该检测试剂盒将只识别天然和重组的人IL-23。Principle of the method 方法原理The Human IL-23 solid-phase sandwich ELISA (enzyme-linked immunosorbent assay) is designed to measure the amount of the target bound between a matched antibody pair. A target-specific antibody has been pre-coated in the wells of the supplied microplate. Samples, standards, or controls are then added into these wells and bind to the immobilized (capture) antibody. The sandwich is formed by the addition of the second (detector) antibody, a substrate solution is added that reacts with the enzyme-antibody-target complex to produce measurable signal. The intensity of this signal is directly proportional to the concentration of target present in the original specimen.人IL-23固相夹心ELISA（酶联免疫吸附测定）旨在测量匹配的抗体对之间结合的靶标量。已在提供的微孔板的孔中预包被了靶标特异性抗体。然后将样品，标准液或质控品添加到这些孔中，并与固定的（捕获）抗体结合。通过添加第二（检测）抗体形成三明治，添加底物溶液，该底物溶液与酶-抗体-靶标复合物反应以产生可测量的信号。该信号的强度与原始样品中存在的靶标浓度成正比。Rigorous validation 严格验证Each manufactured lot of this ELISA kit is quality tested for criteria such as sensitivity, specificity, precision, and lot-to-lot consistency. See manual for more information on validation.此ELISA试剂盒的每批生产都经过质量测试，其标准包括敏感性，特异性，精密度和批次间一致性。有关验证的更多信息，请参见手册。Target information 靶标信息IL-23 is a heterodimeric cytokine composed of the p40 subunit of IL-12 that is disulfide-linked with to two subunits, a p19 subunit unique to IL-23, and a p40 subunit that is shared with IL-12. IL-23 interacts with IL-12Rbeta1 and a beta2-like receptor subunit with STAT4 binding domain, IL-23R. IL-23 is secreted by activated mouse and human dendritic cells and is involved in the inflammation process and associated with autoimmune diseases. Mouse IL-23 was found not to induce significant amounts of IFN-gamma, induces strong proliferation of memory T cells (but not naive T cells), and activate mouse memory T cells to produce the proinflammatory cytokine IL-17. On the other hand, human IL-23 induces proliferation of memory T cells, induces moderate levels of IFN-gamma, and is produced by naive and memory T cells. IL-23 plays an important role in stimulating memory T-cells, and is required for the induction, expansion, maintenance, and downstream effector functions of Th17 cells, which play a vital role in upregulating neutrophil chemokines and various pro-inflammatory cytokines. IL-23 interacts with the receptors IL-12R beta1 and IL-23R to activate the Jak-Stat signaling cascade. IL-23 has been shown to possess potent anti-tumor and anti-metastatic activity in mouse models of cancer, suggesting a potential role for IL-23 in therapeutic treatment of cancer.IL-23是一种异源二聚体细胞因子，由与两个亚基二硫键连接的IL-12 p40亚基，IL-23独有的p19亚基和与IL-12共有的p40亚基组成。 IL-23与IL-12Rbeta1和具有STAT4结合结构域IL-23R的beta2样受体亚基相互作用。 IL-23由活化的小鼠和人树突状细胞分泌，并参与炎症过程并与自身免疫性疾病相关。发现小鼠IL-23不会诱导大量的IFN-γ，不会诱导记忆T细胞（而非幼稚T细胞）强烈增殖，并激活小鼠记忆T细胞以产生促炎性细胞因子IL-17。另一方面，人IL-23诱导记忆T细胞增殖，诱导中等水平的IFN-γ，并由幼稚和记忆T细胞产生。 IL-23在刺激记忆性T细胞中起重要作用，并且是Th17细胞的诱导，扩增，维持和下游效应子功能所必需的，而Th17细胞在上调中性粒细胞趋化因子和各种促炎性细胞因子中起着至关重要的作用。 IL-23与受体IL-12R beta1和IL-23R相互作用以激活Jak-Stat信号级联反应。 IL-23已显示在癌症小鼠模型中具有有效的抗肿瘤和抗转移活性，表明IL-23在癌症的治疗中具有潜在的作用。For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.仅供研究使用。不用于诊断过程。未经明确授权不得转售。

数据：

IL-23 Human ELISA KitRepresentative standard curve for Human IL-23 ELISA

技术参数

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IL-23 Human ELISA Kit ELISA试剂盒,IL-23 Human ELISA Kit/人IL-23 ELISA试剂盒

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