Galectin 3 Monoclonal Antibody (eBioM3/38 (M3/38)), eBioscience/Galectin 3单克隆抗体（eBioM3 / 38（M3 / 38））

货号：BMS1043

规格：100 µg

价格：3679

产品类型：流式抗体

品牌：eBioscience

物种：人

宿主：大鼠

抗体亚型：IgG2a, kappa

克隆号：eBioM3/38 (M3/38)

荧光染料：其它

类型:	单抗	同型对照：
浓度：	1 mg/mL	用法：	Assay-Dependent（ELISA)；Assay-Dependent(WB)；Assay-Dependent(Flow)；Assay-Dependent(IHC)；Assay-Dependent(IP)

产品详细信息Description: The Anti-human Galectin-3 (M3/38) antibody recognizes an epitope in the N-terminal half of lectin. Galectins are a family of animal lectins which appear to exhibit a variety of biological functions. Galectin 3 (aka LGALS3, galactose-specific soluble lectin 3, Mac-2, L-29) is one of the more extensively studied members of this family and is a 30 kDa beta-galactoside-binding protein. Due to a C-terminal carbohydrate binding site, Galectin 3 is capable of binding IgE and mammalian cellsurfaces only when homodimerized or homo-oligomerized. Galectin 3 is normally distributed in epithelia of many organs and various inflammatory cells, including macrophages, as well as dendritic cells and Kupffer cells. The expression of this lectin is up- regulated during inflammation, cell proliferation, cell differentiation and through trans-activation by viral proteins.Applications Tested: ELISA, Flow Cytometry, Immunohistochemistry, Immunoprecipitation, Western Blotting.靶标信息Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis. In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation ofmast cells.

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