TNF alpha Polyclonal Antibody, eBioscience/TNF alpha多克隆抗体

货号：BMS175

规格：100 µg

价格：2806

产品类型：抗体和ELISA

品牌：eBioscience

类型:	多抗	同型对照：
浓度：	1 mg/mL	用法：	Assay-Dependent（ELISA)；Assay-Dependent(WB)；Assay-Dependent(FN)

产品详细信息Description: BMS175 is a polyclonal Antibody thatreacts with rat TNF-alpha.Applications Tested: ELISA, Functional Studies (Blocking), Western Blotting.Purity: >99%.靶标信息TNF alpha is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophage and bind to its receptors, TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. TNF alpha is involved in the regulation of immune cells, cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. TNF alpha exists as a multimer of two, three, or five noncovalently linked units, but shows a single 17 kDa band following SDS-PAGE under non-reducing conditions. Knockout studies in mice also suggested the neuroprotective function of TNF alpha, and has been observed to causes tumor necrosis when injected into tumor-bearing mice. Other functions of TNF-alpha include its role in the immune response to bacterial, viral, parasitic and certain fungal infections, as well as its role in the necrosis of specific tumors. TNF alpha causes cytolysis or cytostasis of certain transformed cells, being synergistic with interferon-gamma in its cytotoxicity. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer.

数据：

TNF alpha Antibody (BMS175)Oxidative medicine and cellular longevity 2018 -Figure 5 Stevia prevents the expression of proinflammatory cytokines in chronic liver damage. Protein levels of TNF- alpha (a), IL-1 beta (b), IL-6 (c), and IL-10 (d) in samples of liver tissue were determined by Western blot analysis of the control, CCl 4 -, CCl 4 + stevia-, and stevia-treated rats. beta -actin was used as a control. The values are expressed as the fold increase of OD normalized to the control group values (control = 1). Each bar represents the mean value of three rats +- SE ( n = 3). a P < 0.05 versus the control group; b P < 0.05 versus the CCl 4 group.

参考文献：

1. Oxidative medicine and cellular longevityStevia Prevents Acute and Chronic Liver Injury Induced by Carbon Tetrachloride by Blocking Oxidative Stress through Nrf2 Upregulation.2. PloS oneElectroacupuncture-like stimulation at the Baihui (GV20) and Dazhui (GV14) acupoints protects rats against subacute-phase cerebral ischemia-reperfusion injuries by reducing S100B-mediated neurotoxicity.3. Pediatric researchLipopolysaccharide preconditioning reduces neuroinflammation against hypoxic ischemia and provides long-term outcome of neuroprotection in neonatal rat.

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