Histone H3 Polyclonal Antibody/组蛋白H3多克隆抗体

货号：PA5-49579

规格：100 µL

价格：4693

产品类型：抗体和染料

品牌：Thermo Fisher

抗原：Peptide sequence around aa.8~12 (R-K-S-T-G) derive

物种：人/小鼠/大鼠

宿主：兔

抗体亚型：IgG

荧光染料：其它

类型:	多抗	同型对照：
浓度：	1 mg/mL	用法：	1.5 µg/1x10^6 cells(ChIP)；1:100-1:200(ICC)；1:100-1:200(IF)；1:1,000(WB)

产品详细信息The antibody detects endogenous level of total Histone H3 protein.靶标信息Histone H3 is one of the DNA-binding proteins found in the chromatin of all eukaryotic cells. H3 along with four core histone proteins binds to DNA forming the structure of the nucleosome. Histones play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. Post translationally, histones are modified in a variety of ways to either directly change the chromatin structure or allow for the binding of specific transcription factors. The N-terminal tail ofhistone H3 protrudes from the globular nucleosome core and can undergo several different types of post-translational modification that influence cellular processes. These modifications include the covalent attachment of methyl or acetyl groups to lysine and arginine amino acids and the phosphorylation of serine or threonine.

数据：

Histone H3 Antibody (PA5-49579)Antibody specificity was demonstrated through detection of enrichment of the target protein at specific gene loci. Chromatin Immunoprecipitation (ChIP) was performed using anti-H3 polyclonal (Catalog# PA5-49579) with relevant positive and negative target genes/ binding sites. Histone H3 Antibody (PA5-49579) in IFImmunofluorescent analysis of HIST1H3A in methanol-fixed Hela cells. Samples were probed using a HIST1H3A polyclonal antibody (Product # PA5-49579).

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