Estrogen Receptor alpha Monoclonal Antibody (TE111.5D11)/雌激素受体α单克隆抗体（TE111.5D11）

货号：MA1-12692

规格：100 µg

价格：8705

产品类型：抗体和染料

品牌：Thermo Fisher

抗原：C-terminal fragment (aa 302-595) of human ER expre

物种：其它

宿主：小鼠

抗体亚型：其它

克隆号：TE111.5D11

荧光染料：其它

类型:	单抗	同型对照：
浓度：	1 mg/mL	用法：	Assay Dependent(ChIP)；Assay Dependent(GS)；2 µg/mL protein lysate(IP)；Assay Dependent(Neu)；1-2 µg/mL(WB)

产品详细信息A suggested positive control for this product is T47D cells.靶标信息Estrogen Receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptors. The estrogen receptor is a ligand-activated transcription factor, that when bound to estrogen hormone, induces a conformational change that allows dimerization and binding to estrogen response elements (ERE) in DNA. When bound to EREs, ER can positively or negatively regulate gene transcription through the recruitment of coactivator or corepressor proteins. There are two different formsof the estrogen receptor, alpha and beta, encoded by separate genes (ESR1 and ESR2, respectively). Due to alternative RNA splicing, at least 4 estrogen receptor-alpha isoforms are known to exist (Isoform 1 (66 kDa), Isoform 2 (53 kDa), Isoform 3 (47 kDa), Isoform 4 (35 kDa)). Estrogen receptors are widely expressed in different tissue types and are essential for sexual development and reproductive function. They also play a role in other tissues such as bone. Estrogen receptors are involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis.

数据：

Estrogen Receptor alpha Antibody (MA1-12692) in WBWestern blot analysis of Estrogen Receptor alpha using a monoclonal antibody (Product # MA1-12692).

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参考文献：

1. Cancer discoveryTumor Cell-Independent Estrogen Signaling Drives Disease Progression through Mobilization of Myeloid-Derived Suppressor Cells.2. Scientific reportsMALAT1 and HOTAIR Long Non-Coding RNAs Play Opposite Role in Estrogen-Mediated Transcriptional Regulation in Prostate Cancer Cells.3. The Journal of biological chemistryEstrogen receptor α L543A,L544A mutation changes antagonists to agonists, correlating with the ligand binding domain dimerization associated with DNA binding activity.4. International journal of cancerNovel senescence associated gene, YPEL3, is repressed by estrogen in ER+ mammary tumor cells and required for tamoxifen-induced cellular senescence.5. Molecular human reproductionDifferential actions of estrogen and SERMs in regulation of the actin cytoskeleton of endometrial cells.

技术参数

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