Human DNMT3A ELISA Kit ELISA试剂盒,Human DNMT3A ELISA Kit/人DNMT3A ELISA试剂盒-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

Human DNMT3A ELISA Kit ELISA试剂盒,Human DNMT3A ELISA Kit/人DNMT3A ELISA试剂盒

2024-10-23

Human DNMT3A ELISA Kit/人DNMT3A ELISA试剂盒

货号：EH157RB,EH157RBX5,EH157RBX10

规格：96 tests,5X96 tests,10X96 tests

价格：6641,29884,57271

产品类型：Platinum ELISA

品牌：Thermo Fisher

物种：人

宿主：其它

抗体亚型：其它

荧光染料：其它

灵敏度	1.4 ng/mL
检测范围	1.4-300 ng/mL
样本类型/体积	血清 50 μL 血浆 50 μL 上清液 50 μL
操作时间	1 hr 20 min
测试时间	4 hr 45 min
Homogenous (no wash)	No
批间变异系数（CV）	<12%
批内变异系数（CV）	<10%
仪器设备	Colorimetric Microplate Reader 酶标仪
规格	5 x 96 Tests
组份	- 预包被96孔板 - 标准品 - 测定稀释浓缩液 - 生物素化检测抗体 - SAV-HRP - 洗涤液 - 显色剂 - 终止液 - 胶板盖
储存温度	2-8℃
Protein name	DNMT3A
Protein aliases	DNA (cytosine-5)-methyltransferase 3A, DNA (cytosine-5-)-methyltransferase 3 alpha, DNA cytosine methyltransferase 3A2, DNA methyltransferase HsaIIIA, DNA MTase HsaIIIA, Dnmt3a
物种（Tested）	人
试剂盒类型	Sandwich ELISA Kit
标记（染料）	HRP
检测抗体偶联物	Biotin
Gene aliases	DNMT3A, DNMT3A2, M.HsaIIIA, TBRS
Gene ID	(Human) 1788
Gene symbol	DNMT3A
UniProt ID	(Human) Q9Y6K1

Human DNMT3A quantitates human DNMT3A in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant human DNMT3A.人DNMT3A定量检测血清，血浆，上清液中的人DNMT3A。该检测试剂盒将专门识别天然和重组人DNMT3A。Target information 靶标信息Methylation of DNA at cytosine residues plays an important role in regulation of gene expression, genomic imprinting and is essential for mammalian development. Hypermethylation of CpG islands in tumor suppressor genes or hypomethylation of bulk genomic DNA may be linked with development of cancer. To date, 3 families of mammalian DNA methyltransferase genes have been identified which include Dnmt1, Dnmt2 and Dnmt3. Dnmt1 is constitutively expressed in proliferating cells and inactivation of this gene causes global demethylation of genomic DNA and embryonic lethality. Dnmt2 is expressed at low levels in adult tissues and its inactivation does not affect DNA methylation or maintenance of methylation. The Dnmt3 family members, Dnmt3a and Dnmt3b, are strongly expressed in ES cells but their expression is down regulated in differentiating ES cells and is low in adult somatic tissue. Recently, it has been shown that naturally occurring mutations of Dnmt3b gene occurs in patients with a rare autosomal recessive disorder, termed ICF (immunodeficiency, centromeric instability, and facial anomalies) syndrome.胞嘧啶残基处的DNA甲基化在调节基因表达，基因组印迹中起重要作用，并且对哺乳动物的发育至关重要。肿瘤抑制基因中CpG岛的甲基化过高或整体基因组DNA的甲基化过低可能与癌症的发展有关。迄今为止，已经鉴定了3个哺乳动物DNA甲基转移酶基因家族，包括Dnmt1，Dnmt2和Dnmt3。 Dnmt1在增殖细胞中组成性表达，并且该基因的失活导致基因组DNA的整体去甲基化和胚胎致死性。 Dnmt2在成人组织中低水平表达，其失活不会影响DNA甲基化或维持甲基化。 Dnmt3家族成员Dnmt3a和Dnmt3b在ES细胞中强烈表达，但在分化的ES细胞中其表达下调，而在成人体细胞中则低。最近，已经显示出Dnmt3b基因的自然发生的突变发生在罕见的常染色体隐性遗传疾病的患者中，这种疾病被称为ICF（免疫缺陷，着丝粒不稳定性和面部异常）综合征。For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.仅供研究使用。不用于诊断过程。未经明确授权不得转售。

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Human DNMT3A ELISA Kit ELISA试剂盒,Human DNMT3A ELISA Kit/人DNMT3A ELISA试剂盒

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