Human IGF2R ELISA Kit ELISA试剂盒,Human IGF2R ELISA Kit/人IGF2R ELISA试剂盒-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

Human IGF2R ELISA Kit ELISA试剂盒,Human IGF2R ELISA Kit/人IGF2R ELISA试剂盒

2024-10-23

Human IGF2R ELISA Kit/人IGF2R ELISA试剂盒

货号：EH251RB,EH251RBX5,EH251RBX10

规格：96 tests,5X96 tests,10X96 tests

价格：6641,29884,57271

产品类型：Platinum ELISA

品牌：Thermo Fisher

物种：人

宿主：其它

抗体亚型：其它

荧光染料：其它

灵敏度	0.27 ng/mL
检测范围	0.27-200ng/mL
样本类型/体积	血清 50 μL 血浆 50 μL 上清液 50 μL
操作时间	1 hr 20 min
测试时间	4 hr 45 min
Homogenous (no wash)	No
批间变异系数（CV）	<12%
批内变异系数（CV）	<10%
仪器设备	Colorimetric Microplate Reader 酶标仪
规格	5 x 96 Tests
组份	- 预包被96孔板 - 标准品 - 测定稀释浓缩液 - 生物素化检测抗体 - SAV-HRP - 洗涤液 - 显色剂 - 终止液 - 胶板盖
储存温度	2-8℃
Protein name	IGF2R
Protein aliases	300 kDa mannose 6-phosphate receptor, Cation-independent mannose-6-phosphate receptor, CD222, CI Man-6-P receptor, IGF-II receptor, Insulin-like growth factor 2 receptor, Insulin-like growth factor II receptor, M6P/IGF2 receptor, M6P/IGF2R, MPR 300
物种（Tested）	人
试剂盒类型	Sandwich ELISA Kit
标记（染料）	HRP
检测抗体偶联物	Biotin
Gene aliases	CD222, CI-M6PR, CIMPR, IGF2R, M6P-R, M6P/IGF2R, MPR 300, MPR1, MPR300, MPRI
Gene ID	(Human) 3482
Gene symbol	IGF2R
UniProt ID	(Human) P11717

Human IGF2R quantitates human IGF2R in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant human IGF2R.人IGF2R定量检测血清，血浆，上清液中的人IGF2R。该检测试剂盒将只识别天然和重组人IGF2R。Target information 靶标信息Lysosomal enzymes containing one or two mannose 6-phosphate (man6P) moieties are moved about in the cell by two distinct but interconnected cycles by means of approximately 300 kDa cation independent mannose 6-phospate receptors (CI-MPR). The biosynthetic cycle refers to the MPR transport of newly synthesized lysosomal enzymes from the trans Golgi network to late endosomes or early lysosomes. The endocytic cycle transports extracellular lysosomal enzymes from the plasma membrane via clathrin-coated vesicles to early endosomes. The entire pool of MPRs cycles between these cellular compartments every 3 hours. The steady state distribution of MPR's is predominantly within late endosomes, fewer in the trans Golgi network and approximately 10 % at cell surface. In addition to its man6P binding activity, the MPR contains a separate binding site for the type II insulin-like growth factor and is capable of binding both man6P and IGF-II simultaneously. An approximately 240 kDa soluble, truncated form, representing the extracellular domain of the protein, has also been found circulating in serum and is capable of binding both ligands.包含一个或两个甘露糖6-磷酸酯（man6P）部分的溶酶体酶通过两个独立但相互关联的循环，通过约300 kDa阳离子非依赖性甘露糖6-磷酸酯受体（CI-MPR）在细胞中移动。生物合成循环是指新合成的溶酶体酶从反式高尔基体网络到晚期内体或早期溶酶体的MPR转运。内吞循环将胞外溶酶体酶从质膜通过网格蛋白包被的囊泡转运至早期的内体。整个MPR池每3小时在这些细胞隔室之间循环一次。 MPR's的稳态分布主要在晚期内体中，反式高尔基体网络中较少，而在细胞表面约10％。除了其man6P结合活性外，MPR还包含一个与II型胰岛素样生长因子结合的结合位点，并且能够同时结合man6P和IGF-II。还发现代表蛋白质的细胞外结构域的约240kDa可溶的，截短的形式在血清中循环并且能够结合两个配体。For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.仅供研究使用。不用于诊断过程。未经明确授权不得转售。

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Human IGF2R ELISA Kit ELISA试剂盒,Human IGF2R ELISA Kit/人IGF2R ELISA试剂盒

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