Human Mcl-1/Bcl2L3 ELISA Kit ELISA试剂盒,Human Mcl-1/Bcl2L3 ELISA Kit/人Mcl-1 / Bcl2L3 ELISA试剂盒-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

Human Mcl-1/Bcl2L3 ELISA Kit ELISA试剂盒,Human Mcl-1/Bcl2L3 ELISA Kit/人Mcl-1 / Bcl2L3 ELISA试剂盒

2024-10-24

Human Mcl-1/Bcl2L3 ELISA Kit/人Mcl-1 / Bcl2L3 ELISA试剂盒

货号：EH317RB,EH317RBX5,EH317RBX10

规格：96 tests,5X96 tests,10X96 tests

价格：6641,29884,57271

产品类型：Platinum ELISA

品牌：Thermo Fisher

物种：人

宿主：其它

抗体亚型：其它

荧光染料：其它

灵敏度	0.13 ng/mL
检测范围	0.13-25 ng/mL
样本类型/体积	血清 50 μL 血浆 50 μL 上清液 50 μL
操作时间	1 hr 20 min
测试时间	4 hr 45 min
Homogenous (no wash)	No
批间变异系数（CV）	<12%
批内变异系数（CV）	<10%
仪器设备	Colorimetric Microplate Reader 酶标仪
规格	5 x 96 Tests
组份	- 预包被96孔板 - 标准品 - 测定稀释浓缩液 - 生物素化检测抗体 - SAV-HRP - 洗涤液 - 显色剂 - 终止液 - 胶板盖
储存温度	2-8℃
Protein name	MCL-1
Protein aliases	Bcl-2-like protein 3, Bcl-2-related protein EAT/mcl1, Bcl2-L-3, Induced myeloid leukemia cell differentiation protein Mcl-1, mcl1/EAT, myeloid cell leukemia 1, myeloid cell leukemia ES, myeloid cell leukemia sequence 1 (BCL2-related)
物种（Tested）	人
试剂盒类型	Sandwich ELISA Kit
标记（染料）	HRP
检测抗体偶联物	Biotin
Gene aliases	bcl2-L-3, BCL2L3, EAT, Mcl-1, MCL1, MCL1-ES, mcl1/EAT, MCL1L, MCL1S, TM
Gene ID	(Human) 4170
Gene symbol	MCL1
UniProt ID	(Human) Q07820

Human Mcl-1/Bcl2L3 quantitates human Mcl-1/Bcl2L3 in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant human Mcl-1/Bcl2L3.人Mcl-1 / Bcl2L3定量检测血清，血浆，上清液中的人Mcl-1 / Bcl2L3。该检测试剂盒将专门识别天然和重组人Mcl-1 / Bcl2L3。Target information 靶标信息MCL1 (Myeloid cell leukemia-1) belongs to the Bcl-2 family and is involved in programing, differentiation and concomitant maintenance of cell viability, but not of proliferation. Isoform 1 of MCL1 inhibits apoptosis while isoform 2 promotes it. The carboxy terminal of MCL1 and bcl-2 share significant sequence homology. Expression of MCL1 is increased upon exposure of ML-1 cells to various types of DNA damaging agents (e.g. ionizing radiation, ultraviolet radiation, and alkylating drugs) along with increases in GADD45 and Bax and a decrease in bcl-2. Enhanced expression of MCL1, prominently associated with mitochondria, complements the continued expression of bcl-2 in ML-1 cells undergoing differentiation. Like bcl-2, MCL1 has the capacity to promote cell viability under conditions that otherwise cause apoptosis. While the mechanism by which MCL1 inhibits apoptosis is not known, it is thought that it may heterodimerize and neutralize pro-apoptotic members of the Bcl-2 family such as Bim or Bak. MCL1 was originally identified in differentiating myeloid cells, but has since been shown to be expressed in multiple cell types. MCL1 is essential for embryogenesis and for the development and maintenance of B and T lymphocytes in animals. MCL1 exists as at least two distinct isoforms designated MCL1L and MCL1S. In marked contrast to the larger isoform of MCL1, overexpression of MCL1S promotes cell death.MCL1（髓样细胞白血病-1）属于Bcl-2家族，参与细胞活力（而不是增殖）的编程，分化和伴随维持。 MCL1的同工型1抑制凋亡，而同工型2促进凋亡。 MCL1和bcl-2的羧基末端具有明显的序列同源性。当ML-1细胞暴露于各种类型的DNA破坏剂（例如电离辐射，紫外线辐射和烷基化药物）后，MCL1的表达会增加，同时GADD45和Bax的增加以及bcl-2的减少。 MCL1的增强表达，与线粒体显着相关，补充了bcl-2在经历分化的ML-1细胞中的持续表达。像bcl-2一样，MCL1具有在否则会导致细胞凋亡的条件下促进细胞存活的能力。虽然尚不知道MCL1抑制细胞凋亡的机制，但人们认为MCL1可以异源二聚化和中和Bcl-2家族的促凋亡成员，例如Bim或Bak。 MCL1最初是在分化骨髓细胞中鉴定的，但自那以后已被证明在多种细胞类型中表达。 MCL1对于动物的胚胎发生以及B和T淋巴细胞的发育和维持至关重要。 MCL1以至少两个不同的同工型存在，分别命名为MCL1L和MCL1S。与MCL1的较大同工型形成鲜明对比的是，MCL1S的过表达促进细胞死亡。For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.仅供研究使用。不用于诊断过程。未经明确授权不得转售。

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Human Mcl-1/Bcl2L3 ELISA Kit ELISA试剂盒,Human Mcl-1/Bcl2L3 ELISA Kit/人Mcl-1 / Bcl2L3 ELISA试剂盒

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