Human APE1/APEX1 ELISA Kit ELISA试剂盒,Human APE1/APEX1 ELISA Kit/人APE1 / APEX1 ELISA试剂盒-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

Human APE1/APEX1 ELISA Kit ELISA试剂盒,Human APE1/APEX1 ELISA Kit/人APE1 / APEX1 ELISA试剂盒

2024-10-24

Human APE1/APEX1 ELISA Kit/人APE1 / APEX1 ELISA试剂盒

货号：EH32RB,EH32RBX5,EH32RBX10

规格：96 tests,5X96 tests,10X96 tests

价格：6641,29884,57271

产品类型：Platinum ELISA

品牌：Thermo Fisher

物种：人

宿主：其它

抗体亚型：其它

荧光染料：其它

灵敏度	0.23 ng/mL
检测范围	0.23-50 ng/mL
样本类型/体积	血清 50 μL 血浆 50 μL 上清液 50 μL
操作时间	1 hr 20 min
测试时间	4 hr 45 min
Homogenous (no wash)	No
批间变异系数（CV）	<12%
批内变异系数（CV）	<10%
仪器设备	Colorimetric Microplate Reader 酶标仪
规格	5 x 96 Tests
组份	- 预包被96孔板 - 标准品 - 测定稀释浓缩液 - 生物素化检测抗体 - SAV-HRP - 洗涤液 - 显色剂 - 终止液 - 胶板盖
储存温度	2-8℃
Protein name	APE1
Protein aliases	AP endonuclease 1, AP endonuclease class I, AP lyase, APEN, APEX nuclease, APEX nuclease (multifunctional DNA repair enzyme) 1, Apurinic-apyrimidinic endonuclease 1, apurinic/apyrimidinic (abasic) endonuclease, deoxyribonuclease (apurinic or apyrimidinic), DNA-(apurinic or apyrimidinic site) lyase, mitochondrial, protein REF-1, Redox factor-1, REF-1
物种（Tested）	人
试剂盒类型	Sandwich ELISA Kit
标记（染料）	HRP
检测抗体偶联物	Biotin
Gene aliases	APE, APE1, APEN, APEX, APEX1, APX, HAP1, REF1
Gene ID	(Human) 328
Gene symbol	APEX1
UniProt ID	(Human) P27695

Human APE1/APEX1 quantitates human APE1/APEX1 in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant human APE1/APEX1.人APE1 / APEX1定量检测血清，血浆，上清液中的人APE1 / APEX1。该检测试剂盒将专门识别天然和重组人APE1 / APEX1。Target information 靶标信息Mammalian apurinic/apyrimidinic endonuclease (APE/ref-1) is a multifunctional, bipartite enzyme that plays an important role in numerous, cellular functions. APE is responsible for repairing abasic sites in DNA and in regulating the redox state of other proteins that play roles in oxidative signaling, transcription factor regulation (Fos, Jun, NF-kB, Myb, HIF-1 alpha, CREB, Pax), cell cycle control (p53), and apoptosis. The most common form of DNA damage is the creation of abasic sites which are brought about through spontaneous loss or oxidative DNA damage, through chemically initiated hydrolysis (chemotherapy), ionizing radiation, UV irradiation, oxidizing agents, and removal of modified bases by DNA glycosylases. APE is differentially expressed during development and in different tissues. This protein has diverse subcellular localization patterns which support the possibility of its interaction with numerous, other cellular proteins in addition to DNA repair within the nucleus. Regulation of APE by phosphorylation is mediated, at least in part, by casein kinase II. Increases in APE message and protein levels are observed upon the reintroduction of oxygen to hypoxic cells, and in some malignant tissue relative to normal tissue. Decreases in APE expression have been associated with the induction of cellular apoptosis.哺乳动物的嘌呤/嘧啶内切核酸酶（APE / ref-1）是一种多功能的两部分酶，在许多细胞功能中起着重要的作用。 APE负责修复DNA中的无碱基位点，并调节在氧化信号，转录因子调节（Fos，Jun，NF-kB，Myb，HIF-1 alpha，CREB，Pax），细胞中起作用的其他蛋白质的氧化还原状态。周期控制（p53）和凋亡。 DNA损伤的最常见形式是通过自然引发的损失或氧化性DNA损伤，化学引发的水解（化学疗法），电离辐射，UV辐射，氧化剂以及DNA糖基化酶去除修饰的碱基而引起的无碱基位点的产生。。 APE在发育过程中和在不同组织中差异表达。这种蛋白质具有多样的亚细胞定位模式，不仅支持细胞核内的DNA修复，还支持了它与众多其他细胞蛋白质相互作用的可能性。通过磷酸化对APE的调节至少部分地由酪蛋白激酶II介导。将氧气重新引入低氧细胞以及相对于正常组织的某些恶性组织中，可以观察到APE信息和蛋白质水平的增加。 APE表达的减少与细胞凋亡的诱导有关。For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.仅供研究使用。不用于诊断过程。未经明确授权不得转售。

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Human APE1/APEX1 ELISA Kit ELISA试剂盒,Human APE1/APEX1 ELISA Kit/人APE1 / APEX1 ELISA试剂盒

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