Human Nanog ELISA Kit ELISA试剂盒,Human Nanog ELISA Kit/人Nanog ELISA试剂盒-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

Human Nanog ELISA Kit ELISA试剂盒,Human Nanog ELISA Kit/人Nanog ELISA试剂盒

2024-10-24

Human Nanog ELISA Kit/人Nanog ELISA试剂盒

货号：EH330RB,EH330RBX5,EH330RBX10

规格：96 tests,5X96 tests,10X96 tests

价格：0,0,0

产品类型：Platinum ELISA

品牌：Thermo Fisher

物种：人

宿主：其它

抗体亚型：其它

荧光染料：其它

灵敏度	0.34 ng/mL
检测范围	0.34-80 ng/mL
样本类型/体积	血清 50 μL 血浆 50 μL 上清液 50 μL
操作时间	1 hr 20 min
测试时间	4 hr 45 min
Homogenous (no wash)	No
批间变异系数（CV）	<12%
批内变异系数（CV）	<10%
仪器设备	Colorimetric Microplate Reader 酶标仪
规格	5 x 96 Tests
组份	- 预包被96孔板 - 标准品 - 测定稀释浓缩液 - 生物素化检测抗体 - SAV-HRP - 洗涤液 - 显色剂 - 终止液 - 胶板盖
储存温度	2-8℃
Protein name	Nanog
Protein aliases	hNanog, Homeobox protein NANOG, Homeobox transcription factor Nanog, homeobox transcription factor Nanog-delta 48
物种（Tested）	人
试剂盒类型	Sandwich ELISA Kit
标记（染料）	HRP
检测抗体偶联物	Biotin
Gene aliases	NANOG
Gene ID	(Human) 79923
Gene symbol	NANOG
UniProt ID	(Human) Q9H9S0

Human Nanog quantitates human Nanog in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant human Nanog.人Nanog定量分析血清，血浆，上清液中的人Nanog。该检测试剂盒将专门识别天然和重组人Nanog。Target information 靶标信息NANOG (Nanog homeobox) is a divergent homeodomain protein that directs pluripotency and differentiation of undifferentiated embryonic stem cells. NANOG mRNA is present in pluripotent mouse and human cell lines, and absent from differentiated cells. Human NANOG protein shares 52% overall amino acid identity with the mouse protein, and 85% identity in the homeodomain. Human NANOG maps to gene locus 12p13.31, while the mouse NANOG maps to gene loci 6 F2. Murine embryonic NANOG expression is detected in the inner cell mass of the blastocyst. Research studies have shown that high levels of human NANOG expression in the undifferentiated N-Tera embryonal carcinoma cell line. Further, NANOG is a transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. The role of NANOG in embryonic development suggested that it might be useful in the creation of stem cells that might be useful in cell replacement therapies in the treatment of several degenerative diseases. Artificial stem cells, termed induced pluripotent stem (iPS) cells, can be created by expressing POU5F1 (also known as Oct-4), another germline-specific transcription factor, and the transcription factors Sox2, Klf4 and Lin28 along with c-Myc in mouse fibroblasts. Experiments have demonstrated that iPS cells could be generated using expression plasmids expressing NANOG, Sox2, KlfF4 and c-Myc, eliminating the need for virus introduction, thereby addressing a safety concern for potential use of iPS cells in regenerative medicine. When overexpressed, NANOG promotes cells to enter into S phase and proliferation. Diseases associated with dysfunction in the NANOG protein include tetracarcinoma and germ cell/embryonal cancer.NANOG（Nanog同源盒）是一种发散的同源域蛋白，可指导未分化的胚胎干细胞的多能性和分化。 NANOG mRNA存在于多能小鼠和人细胞系中，而分化细胞中不存在。人NANOG蛋白与小鼠蛋白共有52％的氨基酸同一性，而在同源域中则有85％的同一性。人类NANOG映射到基因座12p13.31，而小鼠NANOG映射到基因座6 F2。在胚泡的内部细胞团中检测到小鼠胚胎NANOG表达。研究表明，人类NANOG在未分化的N-Tera胚胎癌细胞系中表达高水平。此外，NANOG是涉及内部细胞团和胚胎干（ES）细胞增殖和自我更新的转录调节因子。 NANOG在胚胎发育中的作用表明，它可能在创建干细胞中有用，而干细胞可能在细胞替代疗法中用于治疗几种退行性疾病。可以通过表达另一种种系特异性转录因子POU5F1（也称为Oct-4）和转录因子Sox2，Klf4和Lin28以及c-Myc来创建人工干细胞，称为诱导多能干（iPS）细胞。小鼠成纤维细胞。实验已经证明，可以使用表达NANOG，Sox2，KlfF4和c-Myc的表达质粒来生成iPS细胞，从而无需引入病毒，从而解决了在再生医学中潜在使用iPS细胞的安全问题。当过表达时，NANOG促进细胞进入S期并增殖。与NANOG蛋白功能障碍有关的疾病包括四癌和生殖细胞/胚胎癌。For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.仅供研究使用。不用于诊断过程。未经明确授权不得转售。

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Human Nanog ELISA Kit ELISA试剂盒,Human Nanog ELISA Kit/人Nanog ELISA试剂盒

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