SETD1B Polyclonal Antibody

货号：PA5-54491

规格：100 µL

价格：5548

产品类型：标签抗体

品牌：Thermo Fisher

抗原：Recombinant protein corresponding to Human SETD1B

物种：人

宿主：兔

抗体亚型：IgG

荧光染料：其它

类型:	一抗	同型对照：
浓度：	0.2 mg/mL	用法：	0.25-2 µg/mL(ICC);0.25-2 µg/mL(IF);1:50-1:200(IHC)

产品详细信息Immunogen sequence: DSLGMEEEVD IETEAVAPEE RPSMLDEPPL PVGVEEPADS REPPEEPGLS QEGAMLLSPE PPAKEVEARP PLSPERHighest antigen sequence identity to the following orthologs: Mouse - 56%, Rat - 54%. 靶标信息Two distinct signaling pathways activate the host innate immunity against viral infection. One pathway is reliant on members of the Toll-like receptor (TLR) family while the other uses the RNA helicase RIG-I as a receptor for intracellular viral double-stranded RNA as a trigger for the immune response. VISA is a mitochondrial membrane protein that was identified as a critical component in the IFN-b signaling pathways that recruits IRF-3 to RIG-I, leading to its activation and that of NF-kappa-B. VISA is also thought to interact with other components of the innate immune pathway such as the TLR adapter protein TRIF, TRAF2 and TRAF6. VISA also interacts with the IKK-a, IKK-b and IKK-iota kinases through its C-terminal region. Cleavage of this region by the Hepatitis C virus (HCV) protease allows HCV to escape the host immune system. At least three isoforms of VISA are known to exist.

数据：

SETD1B Antibody (PA5-54491) in IF Immunofluorescent staining of SETD1B in human cell line A-431 using a SETD1B Polyclonal Antibody (Product # PA5-54491) shows localization to nucleoplasm. SETD1B Antibody (PA5-54491) in IHC Immunohistochemical staining of SETD1B in human urinary bladder tissue shows strong nuclear positivity. Samples were probed using a SETD1B Polyclonal Antibody (Product # PA5-54491).

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