Human SMAD4 ELISA Kit ELISA试剂盒,Human SMAD4 ELISA Kit/人SMAD4 ELISA试剂盒-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

Human SMAD4 ELISA Kit ELISA试剂盒,Human SMAD4 ELISA Kit/人SMAD4 ELISA试剂盒

2024-10-24

Human SMAD4 ELISA Kit/人SMAD4 ELISA试剂盒

货号：EH429RB,EH429RBX5,EH429RBX10

规格：96 tests,5X96 tests,10X96 tests

价格：6641,29884,57271

产品类型：Platinum ELISA

品牌：Thermo Fisher

物种：人

宿主：其它

抗体亚型：其它

荧光染料：其它

灵敏度	1.3 ng/mL
检测范围	1.3-300 ng/mL
样本类型/体积	上清液 50 μL
操作时间	1 hr 20 min
测试时间	4 hr 45 min
Homogenous (no wash)	No
批间变异系数（CV）	<12%
批内变异系数（CV）	<10%
仪器设备	Colorimetric Microplate Reader 酶标仪
规格	5 x 96 Tests
组份	- 预包被96孔板 - 标准品 - 测定稀释浓缩液 - 生物素化检测抗体 - SAV-HRP - 洗涤液 - 显色剂 - 终止液 - 胶板盖
储存温度	2-8℃
Protein name	SMAD4
Protein aliases	deleted in pancreatic carcinoma locus 4, Deletion target in pancreatic carcinoma 4, MAD homolog 4, Mothers against decapentaplegic homolog 4, mothers against decapentaplegic, Drosophila, homolog of, 4, SMAD 4, SMAD family member 4, SMAD, mothers against DPP homolog 4
物种（Tested）	人
试剂盒类型	Sandwich ELISA Kit
标记（染料）	HRP
检测抗体偶联物	Biotin
Gene aliases	DPC4, JIP, MADH4, MYHRS, SMAD4
Gene ID	(Human) 4089
Gene symbol	SMAD4
UniProt ID	(Human) Q13485

Human SMAD4 quantitates human SMAD4 in supernatant. The assay will exclusively recognize both natural and recombinant human SMAD4.人SMAD4定量检测上清液中的人SMAD4。该检测试剂盒将只识别天然和重组人SMAD4。Target information 靶标信息Smad4 is encoded by the Smad4 gene that is located on chromosome 18 in humans. Smad4 is also known as Smad family member 4, Sma- and Mad-relatedprotein 4 or Mothers against decapentaplegic (MAD) homolog 4. Smad4 contains N-terminal MH1 (MAD homology 1) and C-terminal MH2 (MAD homology 2) globular domains that are involved in DNA binding and protein interactions respectively. Binding of the TGF-beta superfamily of ligands that includes Transforming Growth Factor -beta (TGF-beta) and bone morphogenetic protein (BMP) to its cognate receptor allows phosphorylation of Smad 1, 2, 3, 5 and 8 (R-Smad, Receptor Smad). This signals for heterotrimerization with Smad4 (co-Smad, co-mediator Smad) and translocation of the complex to the nucleus. Inhibitory or antagonistic Smad (I-Smad) that includes Smad 6 and 7, interact with activated R-Smads and attenuate the signaling pathway. Smad4 acts as a tumor suppressor protein by transcriptionally regulating its target genes such as Cyclin D1 (downregulation) and collagen (upregulation) that inhibit cell proliferation. Dephosphorylation regulates nuclear export and nucleocytoplasmic dynamics of Smads.Smad4由位于人类18号染色体上的Smad4基因编码。 Smad4也被称为Smad家族成员4，Sma和Mad相关蛋白4或抗去能力障碍（MAD）同源物4的母亲。Smad4包含球形的N端MH1（MAD同源性1）和C端MH2（MAD同源性2）。分别与DNA结合和蛋白质相互作用有关的结构域。包括转化生长因子-β（TGF-β）和骨形态发生蛋白（BMP）在内的配体的TGF-β超家族与其相关受体的结合可以使Smad 1、2、3、5和8（R-Smad，接收器Smad）。这表明与Smad4（共同Smad，共同介体Smad）的异源三聚化以及复合物向核的转运。包括Smad 6和7的抑制性或拮抗性Smad（I-Smad）与活化的R-Smads相互作用并减弱信号通路。 Smad4通过转录调节抑制细胞增殖的靶基因（如细胞周期蛋白D1（下调）和胶原蛋白（上调））来充当肿瘤抑制蛋白。去磷酸化调节Smads的核输出和核质动力学。For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.仅供研究使用。不用于诊断过程。未经明确授权不得转售。

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Human SMAD4 ELISA Kit ELISA试剂盒,Human SMAD4 ELISA Kit/人SMAD4 ELISA试剂盒

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