Human TLR-2 ELISA Kit ELISA试剂盒,Human TLR-2 ELISA Kit/人TLR-2 ELISA试剂盒-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

Human TLR-2 ELISA Kit ELISA试剂盒,Human TLR-2 ELISA Kit/人TLR-2 ELISA试剂盒

2024-10-24

Human TLR-2 ELISA Kit/人TLR-2 ELISA试剂盒

货号：EH459RB,EH459RBX5,EH459RBX10

规格：96 tests,5X96 tests,10X96 tests

价格：6641,29884,57271

产品类型：Platinum ELISA

品牌：Thermo Fisher

物种：人

宿主：其它

抗体亚型：其它

荧光染料：其它

灵敏度	0.32 ng/mL
检测范围	0.32-80 ng/mL
样本类型/体积	血清 50 μL 血浆 50 μL 上清液 50 μL
操作时间	1 hr 20 min
测试时间	4 hr 45 min
Homogenous (no wash)	No
批间变异系数（CV）	<12%
批内变异系数（CV）	<10%
仪器设备	Colorimetric Microplate Reader 酶标仪
规格	5 x 96 Tests
组份	- 预包被96孔板 - 标准品 - 测定稀释浓缩液 - 生物素化检测抗体 - SAV-HRP - 洗涤液 - 显色剂 - 终止液 - 胶板盖
储存温度	2-8℃
Protein name	TLR2
Protein aliases	CD282, Toll-like receptor 2, Toll/interleukin-1 receptor-like protein 4
物种（Tested）	人
试剂盒类型	Sandwich ELISA Kit
标记（染料）	HRP
检测抗体偶联物	Biotin
Gene aliases	CD282, TIL4, TLR2
Gene ID	(Human) 7097
Gene symbol	TLR2
UniProt ID	(Human) O60603

Human TLR-2 quantitates human TLR-2 in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant human TLR-2.人TLR-2定量检测血清，血浆，上清液中的人TLR-2。该检测试剂盒将只识别天然和重组人TLR-2。Target information 靶标信息TLR2 is a member of the Toll-like receptor (TLR) family which play a fundamental role in pathogen recognition and activation of innate immunity. TLR proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors such as Protein Kinase C (PKC) alpha/beta and NF-kappa-B. TLR2 can form heterodimers with either TLR1 or TLR6, and as a heterodimer, can recognize a variety of bacterial and mycoplasma lipoproteins respectively. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. The various TLRs exhibit different patterns of expression. TLR2 is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-kappaB. TLR2 aids in the recognition of pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. Ten human homologs of TLRs (TLR1-10) have been described. TLR2 is expressed in human cells such as tonsils, microglia, lymph nodes, and appendices, activated B-cells in germinal centers. CD14+ monocytes express the highest level of TLR2 followed by CD15+ granulocytes, CD19+ B-cells, and CD3+ T-cells. The expression of TLR2 on different cell types are regulated by different immune response modifiers. For example, LPS, GM-CSF, IL-1, and IL-10 up regulates TLR2 whereas IL-4, IFN-gamma, and TNF down regulate TLR2 expression in monocytes.TLR2是Toll样受体（TLR）家族的成员，在病原体识别和先天免疫激活中起着基本作用。 TLR蛋白通过衔接子分子（例如MyD88和TIRAP）起作用，以激活各种激酶和转录因子，例如蛋白激酶C（PKC）alpha / beta和NF-κB。 TLR2可以与TLR1或TLR6形成异源二聚体，并且作为异源二聚体，可以分别识别多种细菌和支原体脂蛋白。果蝇对人类而言，TLR是高度保守的，并且在结构和功能上相似。各种TLR表现出不同的表达模式。 TLR2在外周血白细胞中表达最丰富，并通过刺激NF-κB介导宿主对革兰氏阳性细菌和酵母的反应。 TLR2有助于识别在传染原上表达的病原体相关分子模式（PAMP），并介导有效免疫力发展所必需的细胞因子的产生。已经描述了十种TLR的人类同源物（TLR1-10）。 TLR2在人类细胞如扁桃体，小胶质细胞，淋巴结和附件，生发中心的活化B细胞中表达。 CD14 +单核细胞表达最高水平的TLR2，其次是CD15 +粒细胞，CD19 + B细胞和CD3 + T细胞。 TLR2在不同细胞类型上的表达受不同的免疫反应调节剂调节。例如，LPS，GM-CSF，IL-1和IL-10上调TLR2，而IL-4，IFN-γ和TNF下调单核细胞中TLR2的表达。For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.仅供研究使用。不用于诊断过程。未经明确授权不得转售。

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Human TLR-2 ELISA Kit ELISA试剂盒,Human TLR-2 ELISA Kit/人TLR-2 ELISA试剂盒

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