Human Cadherin-11 ELISA Kit ELISA试剂盒,Human Cadherin-11 ELISA Kit/人Cadherin-11 ELISA试剂盒-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

Human Cadherin-11 ELISA Kit ELISA试剂盒,Human Cadherin-11 ELISA Kit/人Cadherin-11 ELISA试剂盒

2024-10-24

Human Cadherin-11 ELISA Kit/人Cadherin-11 ELISA试剂盒

货号：EH61RB,EH61RBX5,EH61RBX10

规格：96 tests,5X96 tests,10X96 tests

价格：6641,29884,57271

产品类型：Platinum ELISA

品牌：Thermo Fisher

物种：人

宿主：其它

抗体亚型：其它

荧光染料：其它

灵敏度	0.8 ng/mL
检测范围	0.8-200 ng/mL
样本类型/体积	血清 50 μL 血浆 50 μL 上清液 50 μL
操作时间	1 hr 20 min
测试时间	4 hr 45 min
Homogenous (no wash)	No
批间变异系数（CV）	<12%
批内变异系数（CV）	<10%
仪器设备	Colorimetric Microplate Reader 酶标仪
规格	5 x 96 Tests
组份	- 预包被96孔板 - 标准品 - 测定稀释浓缩液 - 生物素化检测抗体 - SAV-HRP - 洗涤液 - 显色剂 - 终止液 - 胶板盖
储存温度	2-8℃
Protein name	CDH11
Protein aliases	cadherin 11, type 2, OB-cadherin (osteoblast), Cadherin-11, OB-cadherin, OSF-4, Osteoblast cadherin
物种（Tested）	人
试剂盒类型	Sandwich ELISA Kit
标记（染料）	HRP
检测抗体偶联物	Biotin
Gene aliases	CAD11, CDH11, CDHOB, OB, OSF-4
Gene ID	(Human) 1009
Gene symbol	CDH11
UniProt ID	(Human) P55287

Human Cadherin-11 quantitates human Cadherin-11 in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant human Cadherin-11.人Cadherin-11定量检测血清，血浆，上清液中的人Cadherin-11。该检测试剂盒将专门识别天然和重组人Cadherin-11。Target information 靶标信息This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. All cadherins are single-pass transmembrane proteins with a variable number of 110 amino acid extracellular cadherin (EC) domains. Classical cadherins contain five large N-terminal EC domains, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Based on amino acid alignment, classical cadherins are divided into type I and type II subgroups. Type I cadherins, including cadherins E (epithelial), N (neural), P (placental), and R (retinal) cadherin differ from type I cadherins in their specific amino acid sequences. Type II cadherins include human cadherin-5, -6, -8, -11, and -12. Type II cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Cadherin-11 (OB-Cadherin) is a marker of the loosely connected and migratory cellular elements of the mesenchyme. Strong expression of Cadherin-11 has been noted in brain, spinal cord, bone marrow and bone cells, and is regulated in human endometrial glandular epithelial and stromal cells. Expression of this particular cadherin in osteoblastic cell lines, and its upregulation during differentiation, suggests a specific function in bone development and maintenance. A variant Cadherin-11 gene (variant form) encodes a truncated protein with an unusual cytoplasmic domain not present in other cadherins. The variant protein is generated by alternative splicing, utilizing a 179 bp intronic sequence. Recently, Cadherin-11 mRNA and protein were found to be expressed in most invasive breast cancer cell lines tested but not in non-invasive cell lines, suggesting that Cadherin-11 may be a marker for aggressive, invasive tumor subsets.该基因编码来自钙粘蛋白超家族的II型经典钙粘蛋白，该膜蛋白介导钙依赖性细胞与细胞的粘附。所有钙粘蛋白均为单程跨膜蛋白，具有110个氨基酸可变的细胞外钙粘蛋白（EC）域。经典的钙粘蛋白包含五个大的N末端EC结构域，一个跨膜结构域和一个小的，高度保守的C末端胞质结构域。基于氨基酸比对，经典钙粘着蛋白分为I型和II型亚组。 I型钙粘着蛋白，包括钙粘蛋白E（上皮），N（神经），P（胎盘）和R（视网膜）钙粘蛋白，在其特定氨基酸序列上与I型钙粘蛋白不同。 II型钙粘蛋白包括人钙粘蛋白5，-6，-8，-11和-12。基于缺乏对I型钙粘蛋白特异的HAV细胞粘附识别序列来定义II型钙粘蛋白。 Cadherin-11（OB-Cadherin）是间充质的松散连接和迁移细胞元件的标志。已经在脑，脊髓，骨髓和骨细胞中注意到Cadherin-11的强表达，并且在人子宫内膜腺上皮和基质细胞中受到调节。该特定钙粘着蛋白在成骨细胞系中的表达及其在分化过程中的上调提示了其在骨骼发育和维持中的特定功能。变体Cadherin-11基因（变体形式）编码截短的蛋白质，该蛋白质具有其他钙黏着蛋白中不存在的异常胞质结构域。利用179 bp内含子序列，通过可变剪接产生变异蛋白。最近，发现Cadherin-11 mRNA和蛋白在大多数测试的浸润性乳腺癌细胞系中表达，但在非浸润性细胞系中不表达，这表明Cadherin-11可能是侵袭性，浸润性肿瘤亚群的标志物。For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.仅供研究使用。不用于诊断过程。未经明确授权不得转售。

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Human Cadherin-11 ELISA Kit ELISA试剂盒,Human Cadherin-11 ELISA Kit/人Cadherin-11 ELISA试剂盒

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