SETD2 Polyclonal Antibody

货号：PA5-34934

规格：100 µL

价格：5548

产品类型：标签抗体

品牌：Thermo Fisher

抗原：Recombinant fragment contains a sequence correspon

物种：人

宿主：兔

抗体亚型：IgG

荧光染料：其它

类型:	一抗	同型对照：
浓度：	0.82 mg/mL	用法：	1:100-1:1000(IHC(P)) ;1:500-1:3000(WB)

产品详细信息Recommended positive controls: Raji, K562.Predicted reactivity: Mouse (82%), Rat (87%).Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. 靶标信息Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate. Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation. Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A. Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated allows a quick identification of mismatch DNA to initiate the mismatch repair reaction. H3K36me3 also plays an essential role in the maintenance of a heterochromatic state, by recruiting DNA methyltransferase DNMT3A. H3K36me3 is also enhanced in intron-containing genes, suggesting that SETD2 recruitment is enhanced by splicing and that splicing is coupled to recruitment of elongating RNA polymerase. Required during angiogenesis. Recruited to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression.

数据：

SETD2 Antibody (PA5-34934) in IHC (P)Immunohistochemical analysis of SETD2 in the nucleus of paraffin-embedded HBL435 xenograft using a SETD2 polyclonal antibody (Product # PA5-34934) at a dilution of 1:500 SETD2 Antibody (PA5-34934) in WB Western blot analysis of SETD2 was performed by separating 30 µg of whole cell extract by 5% SDS-PAGE. Proteins were transferred to a membrane and probed with a SETD2 Polyclonal Antibody (Product # PA5-34934) at a dilution of 1:500. The HRP-conjugated anti-rabbit IgG antibody was used to detect the primary antibody.

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