NSD1 Polyclonal Antibody

货号：PA5-65515

规格：100 µL

价格：6049

产品类型：标签抗体

品牌：Thermo Fisher

抗原：Recombinant Human NSD1

物种：人

宿主：兔

抗体亚型：IgG

荧光染料：其它

类型:	一抗	同型对照：
浓度：	0.1 mg/mL	用法：	0.25-2 µg/mL(ICC) ;0.25-2 µg/mL(IF)

产品详细信息Immunogen sequence: INEECSLKCCS SDTKGSPLAS ISKSGKVDGL KLLNNMHEKT RDSSDIETAV VKHVLSELKE LSYRSLGEDV SDSGTSKPSK PLLFSSASSQ NHIPIEPDYK FSTLLMMLKD MHDSKTKEQR LMTAQNLVSYHighest antigen sequence identity to the following orthologs - mouse 91%, rat 90%. 靶标信息This gene encodes a protein containing a SET domain, 2 LXXLL motifs, 3 nuclear translocation signals (NLSs), 4 plant homeodomain (PHD) finger regions, and a proline-rich region. The encoded protein enhances androgen receptor (AR) transactivation, and this enhancement can be increased further in the presence of other androgen receptor associated coregulators. This protein may act as a nucleus-localized, basic transcriptional factor and also as a bifunctional transcriptional regulator. Mutations of this gene have been associated with Sotos syndrome and Weaver syndrome. One version of childhood acute myeloid leukemia is the result of a cryptic translocation with the breakpoints occurring within nuclear receptor-binding Su-var, enhancer of zeste, and trithorax domain protein 1 on chromosome 5 and nucleoporin, 98-kd on chromosome 11. Two transcript variants encoding distinct isoforms have been identified for this gene.

数据：

NSD1 Antibody (PA5-65515) in IFImmunofluorescent staining of NSD1 in human cell line HEK 293 shows localization to nucleus and cytosol. Samples were probed using a NSD1 Polyclonal Antibody (Product # PA5-65515).

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