JAK2 Monoclonal Antibody (691R5)

货号：AHO1352

规格：100 µg

价格：4809

产品类型：标签抗体

品牌：Thermo Fisher

抗原：Recombinant fragment of human JAK2 expressed in E.

物种：人/小鼠/大鼠

宿主：小鼠

抗体亚型：IgG2b, kappa

克隆号：691R5

荧光染料：Alexa Fluor 488

类型:	一抗	同型对照：
浓度：		用法：

靶标信息Janus Activating Kinase 2 (JAK2) is a non-rececptor tyrosine kinase involved in various processes such as cell growth, development, differentiation, and histone modifications. In response to a varitety of cytokine or related factors (e.g., interferon, interleukins), JAKs are activated via phosphorylation at 2 adjacent tyrosine residues. The activation of JAKs can lead to the phosphorylation of STAT (signal transducers and activatiors of transcription) proteins, which dimerize and translocate to the nucleus. Once translocated to the nucleus, the STAT proteins can modify transcription of numerous genes, including interferon-stimulated genes. JAK2 is required for the IFN gamma-receptor complex initiation and JAK1 functions as an amplifier. Some studies have suggested that the role of JAK2 might be performed by Tyk2 and JAK3, if they were positioned correctly within the IFN gamma-receptor complex. Mutations affecting this gene can cause Budd-Chiari syndrome, Polycythemia vera, Thrombocythemia 3, myelofibrosis, or Acute myelogenous leukemia.

数据：

JAK2 Antibody (AHO1352) in WB Proteins from cell extract of human Jurkat cells were resolved by SDS-PAGE and transferred to PVDF. The membranes were incubated with this JAK2 monoclonal antibody (clone 691R5) at a concentration of 1 µg/mL for two hours at room temperature.JAK2 Antibody (AHO1352) PloS one 2013 - Figure 4 Kinase inactive Jak2 is degraded but not aggregated. gamma2A Jak2 -/- were transiently transfected with Jak2-K882E or wild type Jak2, respectively. Equal amounts of cells were incubated at 37 and 40degC, respectively, for the indicated times. The cells were lysed, fractionated and analyzed as in Fig. 3B . The data in this figure are representative of three independent experiments.

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