LSD1 Polyclonal Antibody

货号：PA5-90711

规格：100 µL

价格：4887

产品类型：标签抗体

品牌：Thermo Fisher

抗原：Recombinant fusion protein containing a sequence c

物种：人/小鼠/大鼠

宿主：兔

抗体亚型：IgG

荧光染料：其它

类型:	一抗	同型对照：
浓度：	2.05 mg/mL	用法：	1:50-1:100(ICC);1:50-1:100(IF);1:50-1:100(IHC(P));1:500-1:2000(WB)

产品详细信息Immunogen sequence: LSEDEYYSEE ERNAKAEKEK KLPPPPPQAP PEEENESEPE EPSGVEGAAF QSRLPHDRMT SQEAACFPDI ISGPQQTQKV FLFIRNRTLQ LWLDNPKIQL TFEATLQQLE APYNSDTVLV HRVHSYLERH GLINFGIYKR IKPLPTKKTG KVIIIGSGVS GLAAARQLQS FGMDVTLLEA RDRVGGRVAT FRKGNYVADL GAMVVTGLGG NPMAVVSKQV NMELAKIKQK CPLYEANGQA VPKEKDEMVE Q; Cellular Location: Nucleus靶标信息LSD1 is a histone demethylase that specifically demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. LSD1 contains a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. This protein is a component of several histone deacetylase complexes, though it silences genes by functioning as a histone demethylase. It acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. LSD1 demethylates both mono- and tri-methylted 'Lys-4' of histone H3. This protein may play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3 'Lys-4' on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity. It may also demethylate 'Lys-9' of histone H3, a specific tag for epigenetic transcriptional repression, thereby leading to derepression of androgen receptor target genes. Mutations affecting this gene can result in cleft palate, psychomotor retardation, and distintive facial features.

数据：

LSD1 Antibody (PA5-90711) in ICCImmunocytochemistry-Immunofluorescence analysis of LSD1 was performed in HeLa cells using LSD1 Polyclonal Antibody (Product # PA5-90711). LSD1 Antibody (PA5-90711) in IHCImmunohistochemistry analysis of LSD1 in paraffin-embedded human esophageal using LSD1 Polyclonal Antibody (Product # PA5-90711) at a dilution of 1:200. LSD1 Antibody (PA5-90711) in WBWestern Blot analysis of LSD1 in extracts of various cell lines using LSD1 Polyclonal Antibody (Product # PA5-90711) at a dilution of 1:1000. A HRP Goat Anti-Rabbit IgG (H+L) secondary antibody was used at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST.

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