Canine VEGF-A ELISA Kit ELISA试剂盒,Canine VEGF-A ELISA Kit/犬VEGF-A ELISA试剂盒-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

Canine VEGF-A ELISA Kit ELISA试剂盒,Canine VEGF-A ELISA Kit/犬VEGF-A ELISA试剂盒

2024-10-24

Canine VEGF-A ELISA Kit/犬VEGF-A ELISA试剂盒

货号：EC18RB,EC18RBX5,EC18RBX10

规格：96 Tests,5X96 Tests,10X96 tests

价格：6327,29884,57271

产品类型：Platinum ELISA

品牌：Thermo Fisher

物种：其它

宿主：其它

抗体亚型：其它

荧光染料：其它

灵敏度	6 pg/mL
检测范围	6-1,500 pg/mL
样本类型/体积	血清 50 μL 血浆 50 μL 上清液 50 μL
操作时间	1 hr 20 min
测试时间	4 hr 45 min
Homogenous (no wash)	No
批间变异系数（CV）	<12%
批内变异系数（CV）	<10%
仪器设备	Colorimetric Microplate Reader 酶标仪
规格	5 x 96 Tests
组份	- 预包被96孔板 - 标准品 - 测定稀释浓缩液 - 生物素化检测抗体 - SAV-HRP - 洗涤液 - 显色剂 - 终止液 - 胶板盖
储存温度	2-8℃
Protein name	VEGF
Protein aliases	vascular endothelial growth factor 188, Vascular endothelial growth factor A, Vascular permeability factor, VEGF-A, VPF
物种（Tested）	狗
试剂盒类型	Sandwich ELISA Kit
标记（染料）	HRP
检测抗体偶联物	Biotin
Gene aliases	VEGF, VEGFA
Gene ID	(Dog) 403802
UniProt ID	(Dog) Q9MYV3
Gene symbol	VEGFA

Canine VEGF-A quantitates canine VEGF-A in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant canine VEGF-A.犬VEGF-A定量测定血清，血浆，上清液中的犬VEGF-A。该检测试剂盒将只识别天然和重组犬VEGF-A。Target information 靶标信息VEGF (vascular endothelial growth factor) which is a 45 kDa homodimeric, disulfide-linked glycoprotein involved in angiogenesis which promotes tumor progression and metastasis. VEGF has a variety of effects on vascular endothelium, including the ability to promote endothelial cell viability, mitogenesis, chemotaxis, and vascular permeability. The VEGF family currently includes VEGF-A, VEGF-B, VEGF-C, VEGF-D, VEGF-E, and PIGF. VEGF and its receptor system have been shown to be the fundamental regulators in the cell signaling of angiogenesis. Most tumors have the absolute requirement of angiogenesis, and VEGF has been described as the most potent angiogenic cytokine linked to this process. To date 5 different isoforms of VEGF have been described. These isoforms are generated as the result of alternative splicing from a single VEGF gene. These various isoforms have been shown to bind to two tyrosine-kinase receptors flt-1 (VEGFR-1) and flk-1/KDR (VEGFR-2), which have been found to be expressed almost exclusively on endothelial cells. VEGF and its high-affinity binding receptors, the tyrosine kinases FLK1 and FLT1, are thought to be important for the development of embryonic vasculature. Studies have shown that an alternately spliced form of FLT1 produces a soluble protein, termed sFLT1, which binds vascular endothelial growth factor with high affinity, playing an inhibitory role in angiogenesis. Elevated levels of VEGF is linked to POEMS syndrome (Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal gammopathy, Skin changes) also known as Crow-Fukase syndrome which affects multiple organs in the body.VEGF（血管内皮生长因子）是一种45 kDa的同型二聚体，二硫键连接的糖蛋白，参与血管生成，可促进肿瘤进展和转移。 VEGF对血管内皮具有多种作用，包括促进内皮细胞活力，促有丝分裂，趋化性和血管通透性的能力。 VEGF家族目前包括VEGF-A，VEGF-B，VEGF-C，VEGF-D，VEGF-E和PIGF。 VEGF及其受体系统已被证明是血管新生细胞信号传导中的基本调节因子。大多数肿瘤对血管生成具有绝对的要求，而VEGF被描述为与此过程相关的最有效的血管生成细胞因子。迄今为止，已经描述了5种不同的VEGF同工型。这些同工型是从单个VEGF基因进行选择性剪接的结果。已显示这些各种同工型与两个酪氨酸激酶受体flt-1（VEGFR-1）和flk-1 / KDR（VEGFR-2）结合，发现它们几乎只在内皮细胞上表达。 VEGF及其高亲和力结合受体酪氨酸激酶FLK1和FLT1被认为对胚胎脉管系统的发育很重要。研究表明，FLT1的另一种剪接形式可产生称为sFLT1的可溶性蛋白，该蛋白以高亲和力结合血管内皮生长因子，在血管生成中起抑制作用。 VEGF水平升高与POEMS综合征（多发性神经病，器官肿大，内分泌病，单克隆丙种球蛋白病，皮肤变化）有关，也被称为Crow-Fukase综合征，它会影响体内的多个器官。For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.仅供研究使用。不用于诊断过程。未经明确授权不得转售。

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Canine VEGF-A ELISA Kit ELISA试剂盒,Canine VEGF-A ELISA Kit/犬VEGF-A ELISA试剂盒

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