Mouse FAS/TNFRSF6/Apo-1 ELISA Kit ELISA试剂盒,Mouse FAS/TNFRSF6/Apo-1 ELISA Kit/小鼠FAS / TNFRSF6 / Apo-1 ELISA试剂盒

2024-10-24

Mouse FAS/TNFRSF6/Apo-1 ELISA Kit/小鼠FAS / TNFRSF6 / Apo-1 ELISA试剂盒

货号:EM30RB,EM30RBX5,EM30RBX10

规格:96 Tests,5X96 Tests,10X96 tests

价格:6641,29884,57271

产品类型:Platinum ELISA

品牌:Thermo Fisher

物种:小鼠

宿主:其它

抗体亚型:其它

荧光染料:其它

灵敏度

8.2 pg/mL

检测范围8.2-2,000 pg/mL

样本类型/体积

血清 50 μL

血浆 50 μL

上清液 50 μL

操作时间

1 hr 20 min

测试时间

4 hr 45 min

Homogenous (no wash)

No

批间变异系数(CV)<12%
批内变异系数(CV)<10%

仪器设备

Colorimetric Microplate Reader 酶标仪

规格

5 x 96 Tests

组份

- 预包被96孔板

- 标准品

- 测定稀释浓缩液

- 生物素化检测抗体

- SAV-HRP

- 洗涤液

- 显色剂

- 终止液

- 胶板盖

储存温度

2-8℃

Protein nameFAS (CD95)
Protein aliasesApo-1 antigen, Apoptosis-mediating surface antigen FAS, CD95, Fas (TNF receptor superfamily member), Fas antigen, FASLG receptor, lymphoproliferation, Tumor necrosis factor receptor superfamily member 6

物种(Tested)

小鼠

试剂盒类型

Sandwich ELISA Kit

标记(染料)

HRP

检测抗体偶联物Biotin
Gene aliasesAI196731, APO1, APT1, CD95, Fas, lpr, TNFR6, Tnfrsf6
Gene ID(Mouse) 14102
Gene symbolFas
UniProt ID(Mouse) P25446
Mouse FAS/TNFRSF6/Apo-1 quantitates mouse FAS/TNFRSF6/Apo-1 in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant mouse FAS/TNFRSF6/Apo-1.小鼠FAS / TNFRSF6 / Apo-1定量分析血清,血浆,上清液中的小鼠FAS / TNFRSF6 / Apo-1。该检测试剂盒将专门识别天然和重组小鼠FAS / TNFRSF6 / Apo-1。Target information 靶标信息FAS (Fas, CD95, APO-1) is a 46 kDa transmembrane glycoprotein that functions as a cell death receptor of the TNFR (tumor necrosis factor receptor) superfamily. FAS also exists in a soluble form that weight approximately 26kDa. Stimulation of FAS results in aggregation of its intracellular FAS-associated death domains (FADD), formation of the death-inducing signaling complex (DISC) and activation of caspases. The auto-proteolytic processing of the caspases in the complex trigger a downstream cascade that leads to apoptosis. FAS has been shown to activate NF-kappaB, MAPK3/ERK1, MAPK8/JNK, and is involved in transducing the proliferating signals in normal diploid fibroblast and T cells. At least eight alternatively spliced transcript variants encoding seven distinct isoforms have been described. The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full-length isoform. The Fas/Fas ligand system has been shown to play a role in a number of human diseases such as AIDS, hepatitis and cancer. It is also assumed that induction of apoptosis through FAS ligand pathway is predominantly involved in anti-viral immune responses.FAS(Fas,CD95,APO-1)是一种46 kDa的跨膜糖蛋白,起TNFR(肿瘤坏死因子受体)超家族的细胞死亡受体的作用。 FAS还以重量约26kDa的可溶形式存在。刺激FAS导致其细胞内FAS相关死亡域(FADD)聚集,诱导死亡的信号传导复合物(DISC)形成和胱天蛋白酶激活。复合物中半胱氨酸蛋白酶的自动蛋白水解过程触发下游级联反应,导致细胞凋亡。 FAS已被证明可以激活NF-κB,MAPK3 / ERK1,MAPK8 / JNK,并参与正常二倍体成纤维细胞和T细胞中增殖信号的转导。已经描述了编码八个不同同工型的至少八个选择性剪接的转录变体。缺乏跨膜结构域的同工型可能负调控由全长同工型介导的细胞凋亡。 Fas / Fas配体系统已显示出在许多人类疾病(如艾滋病,肝炎和癌症)中的作用。还假设通过FAS配体途径诱导细胞凋亡主要参与抗病毒免疫反应。For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.仅供研究使用。 不用于诊断过程。 未经明确授权不得转售。

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