Mouse PDGF-AA ELISA Kit ELISA试剂盒,Mouse PDGF-AA ELISA Kit/小鼠PDGF-AA ELISA试剂盒-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

Mouse PDGF-AA ELISA Kit ELISA试剂盒,Mouse PDGF-AA ELISA Kit/小鼠PDGF-AA ELISA试剂盒

2024-10-24

Mouse PDGF-AA ELISA Kit/小鼠PDGF-AA ELISA试剂盒

货号：EM61RB,EM61RBX5,EM61RBX10

规格：96 Tests,5X96 Tests,10X96 tests

价格：6641,28472,54564

产品类型：Platinum ELISA

品牌：Thermo Fisher

物种：小鼠

宿主：其它

抗体亚型：其它

荧光染料：其它

灵敏度	3.2 pg/mL
检测范围	3.2-800 pg/mL
样本类型/体积	血清 50 μL 血浆 50 μL 上清液 50 μL
操作时间	1 hr 20 min
测试时间	4 hr 45 min
Homogenous (no wash)	No
批间变异系数（CV）	<12%
批内变异系数（CV）	<10%
仪器设备	Colorimetric Microplate Reader 酶标仪
规格	5 x 96 Tests
组份	- 预包被96孔板 - 标准品 - 测定稀释浓缩液 - 生物素化检测抗体 - SAV-HRP - 洗涤液 - 显色剂 - 终止液 - 胶板盖
储存温度	2-8℃
Protein name	PDGF-AA
Protein aliases	PDGF subunit A, PDGF-1, Platelet-derived growth factor A chain, Platelet-derived growth factor alpha polypeptide, Platelet-derived growth factor subunit A
物种（Tested）	小鼠
试剂盒类型	Sandwich ELISA Kit
标记（染料）	HRP
检测抗体偶联物	Biotin
Gene aliases	Pdgfa
Gene ID	(Mouse) 18590
Gene symbol	Pdgfa
UniProt ID	(Mouse) P20033

Mouse PDGF-AA quantitates mouse PDGF-AA in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant mouse PDGF-AA.小鼠PDGF-AA定量检测血清，血浆，上清液中的小鼠PDGF-AA。该检测试剂盒将专门识别天然和重组小鼠PDGF-AA。Target information 靶标信息Platelet-derived growth factor (PDGF) was discovered as a major mitogenic factor present in serum but absent from plasma. It was found to be secreted from the alpha -granules of platelets activated during the coagulation of blood to form serum. Subsequent studies have demonstrated that PDGF is not one molecule but three, each a dimeric combination of two distinct but structurally related peptide chains designated A and B. The dimeric isoforms PDGF-AA, AB and BB are differentially expressed in various cell types and their effects are mediated through two distinct receptors, termed alpha and beta. Differences exist in isoform binding to each receptor. In general, PDGF isoforms are potent mitogens for connective tissue cells, including dermal fibroblasts, glial cells, arterial smooth muscle cells and some epithelial and endothelial cells. In addition to its activity as a mitogen, PDGF is chemotactic for fibroblasts, smooth muscle cells, neutrophils and mononuclear cells. Other reported activities for PDGF include stimulation of granule release by neutrophils and monocytes, facilitation of steroid synthesis by Leydig cells, stimulation of neutrophil phagocytosis, inhibition of natural killer (NK) cell activity, stimulation of collagen synthesis, modulation of thrombospondin expression and secretion, stimulation of collagenase activity and secretion, induction of contraction of rat aorta strips in vitro, and transient induction of T cell IL-2 secretion accompanied by a down-regulation of IL-4 and IFN-gamma production, temporary effects that may allow clonal expansion of antigen-activated B and T helper lymphocytes prior to differentiation. PDGF also appears to be ubiquitous in neurons throughout the CNS, where it is suggested to play an important role in neuron survival and regeneration, and in mediation of glial cell proliferation and differentiation.发现血小板衍生的生长因子（PDGF）是血清中存在但血浆中不存在的主要促有丝分裂因子。发现它是从血液凝结形成血清过程中活化的血小板的α颗粒分泌的。随后的研究表明，PDGF不是一个分子而是三个分子，每个都是两个截然不同但在结构上相关的肽链（称为A和B）的二聚体组合。PDGF-AA，AB和BB的二聚体同种型在多种细胞类型及其作用中差异表达通过两个截然不同的受体（称为α和β）介导的β-内酰胺酶。与每个受体结合的同工型存在差异。通常，PDGF同工型是结缔组织细胞的有效促细胞分裂剂，包括真皮成纤维细胞，神经胶质细胞，动脉平滑肌细胞以及某些上皮和内皮细胞。除了作为有丝分裂原的活性外，PDGF还具有成纤维细胞，平滑肌细胞，嗜中性粒细胞和单核细胞的趋化作用。 PDGF的其他报道的活性还包括嗜中性粒细胞和单核细胞刺激颗粒释放，莱伊迪格细胞促进类固醇合成，刺激嗜中性白细胞吞噬作用，抑制自然杀伤（NK）细胞活性，刺激胶原蛋白合成，调节血小板反应蛋白的表达和分泌，刺激胶原酶的活性和分泌，体外诱导大鼠主动脉条的收缩，并短暂诱导T细胞IL-2分泌，同时下调IL-4和IFN-γ的产生，这些暂时的作用可能会导致克隆扩增分化前抗原活化的B和T辅助淋巴细胞的数量。 PDGF似乎在整个CNS的神经元中也普遍存在，因此建议在神经元的存活和再生以及胶质细胞增殖和分化的介导中起重要作用。For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.仅供研究使用。不用于诊断过程。未经明确授权不得转售。

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Mouse PDGF-AA ELISA Kit ELISA试剂盒,Mouse PDGF-AA ELISA Kit/小鼠PDGF-AA ELISA试剂盒

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