69-0459-42 Thermo fisher CD45 Monoclonal Antibody (HI30), eFluor 506,CD45 Monoclonal Antibody (HI30), eFluor 506-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

69-0459-42 Thermo fisher CD45 Monoclonal Antibody (HI30), eFluor 506,CD45 Monoclonal Antibody (HI30), eFluor 506

2024-10-24

CD45 Monoclonal Antibody (HI30), eFluor 506

货号：69-0459-42

规格：100 Tests

价格：2575

产品类型：流式抗体

品牌：Thermo Fisher

物种：人/小鼠

宿主：小鼠

抗体亚型：IgG1, kappa

克隆号：HI30

荧光染料：eFluor 506

抗体类型	单抗	同型对照：	Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), eFluor 506, eBioscience™
浓度：	5 µL/Test	用法：	5 µL (0.5 µg)/test(Flow)
产品详细信息Description: The HI30 monoclonal antibody reacts with all isoforms of human CD45, also known as Leukocyte Common Antigen (LCA). CD45 is expressed by all hematopoietic cells excluding circulating erythrocytes and platelets. The cytoplasmic portion of CD45 has tyrosine phosphatase enzymatic activity and plays an important role in activation of lymphocytes.Applications Reported: This HI30 antibody has been reported for use in flow cytometric analysis.Applications Tested: This HI30antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at 5 µL (0.5 µg) per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test.eFluor® 506 can be excited with the violet laser line (405 nm) and emits at 506 nm. We recommend using a 510/20 band pass filter, or equivalent. Please make sure that your instrument is capable of detecting this fluorochrome.Excitation: 405 nm; Emission: 506 nm; Laser: Violet Laser.Filtration: 0.2 µm post-manufacturing filtered.靶标信息CD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase (PTP) ubiquitously expressed in all nucleated hematopoietic cells, comprising approximately 10% of all surface proteins in lymphocytes. CD45 is absent on non-hematopoietic cell lines, normal and malignant, non-hematopoietic tissues. CD45 glycoprotein is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases. CD45 protein exists as multiple isoforms as a result of alternative splicing, differ in their extracellular domains but share identical transmembrane and cytoplasmic domains. CD45RA is an isoform of the CD45 complex and has restricted expression between different subtypes of lymphoid cells. CD45 isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. CD45 has been shown to be an essential regulator of T- and B-cell antigen receptor signaling and suppresses JAK kinases to regulate cytokine receptor signaling. CD45 is also important in promoting cell survival by modulating integrin-mediated signal transduction pathway, DNA fragmentation during apoptosis and inhibition or upregulation of various immunological functions.
数据
CD45 Antibody (69-0459-42) in FlowStaining of normal human peripheral blood cells with Mouse IgG1 K Isotype Control eFluor® 506 (Product # 69-4714-82) (blue histogram) or Anti-Human CD45 eFluor® 506 (purple histogram). Cells in the lymphocyte gate were used for analysis.
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参考文献：
1.eLifeMechanisms of virus dissemination in bone marrow of HIV-1-infected humanized BLT mice."Published figure using CD45 monoclonal antibody (Product # 69-0459-42) in Flow Cytometry"2.Oncology reportsSingle nucleotide variant profiles of viable single circulating tumour cells reveal CTC behaviours in breast cancer."Published figure using CD45 monoclonal antibody (Product # 69-0459-42) in Flow Cytometry"3.Journal of biological research (Thessalonike, Greece)Evaluation of a simple method for storage of blood samples that enables isolation of circulating tumor cells 96h after sample collection."Published figure using CD45 monoclonal antibody (Product # 69-0459-42) in Flow Cytometry"4.Journal of biological research (Thessalonike, Greece)Evaluation of a simple method for storage of blood samples that enables isolation of circulating tumor cells 96h after sample collection."Published figure using CD45 monoclonal antibody (Product # 69-0459-42) in Flow Cytometry"5.Scientific reportsCirculating tumor cell detection in hepatocellular carcinoma based on karyoplasmic ratios using imaging flow cytometry."Published figure using CD45 monoclonal antibody (Product # 69-0459-42) in Flow Cytometry"

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69-0459-42 Thermo fisher CD45 Monoclonal Antibody (HI30), eFluor 506,CD45 Monoclonal Antibody (HI30), eFluor 506

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