c-Myc Monoclonal Antibody (9 E11)/c-Myc单克隆抗体（9 E11）

货号：AHO0052

规格：100 µg

价格：4786

产品类型：免疫组化一抗

品牌：Thermo Fisher

抗原：A synthetic peptide, corresponding to amino acid r

物种：其它

宿主：小鼠

抗体亚型：IgG2a, kappa

克隆号：9 E11

荧光染料：其它

类型:	单抗	同型对照：
浓度：		用法：	1:20(Flow)；2 µg/mL(ICC)；2 µg/mL(IF)；10 µL(IP)；Assay Dependent(WB)

靶标信息The c-Myc protein is a 62 kDa transcription factor that is encoded by the c-Myc gene on human chromosome 8q24. c-Myc is commonly activated in a variety of tumor cells and plays an important role in cellular proliferation, differentiation, apoptosis and cell cycle progression. The phosphorylation of c-Myc has been investigated and previous studies have suggested a functional association between phosphorylation at Thr58/Ser62 by glycogen synthase kinase 3, cyclin dependent kinase, ERK2 and C-Jun Nterminal Kinase (JNK) in cell proliferation and cell cycle regulation. Studies have shown that c-Myc is essential for vasculogenesis and angiogenesis in tumor development, which distributes blood throughout the cells. The c-myc oncogene (p62 c-myc) is involved in the control of normal cellular proliferation and differentiation, and the deregulated expression of c-Myc induces apoptosis in different cell types. Antibodies against c-myc epitopes recognize overexpressed proteins containing Myc epitope tag fused to either amino- or carboxy-termini of targeted proteins. c-Myc-, N-Myc- and L-Myc-encoded proteins function in cell proliferation, differentiation and neoplastic disease. Amplification of the c-Myc gene has been found in several types of human tumors including lung, breast and colon carcinomas, while the N-Myc gene has been found amplified in neuroblastomas. Translocation of the c-myc locus on chromosome 8 to the immunoglobulin loci on chromosome 14 (heavy chain); 2 (delta light chain); or 22 (light chain) is described in Burkitts lymphoma and other B-cell lymphoproliferative conditions. An aberrant expression of the c-myc gene occurs in tumors of different origins such as colorectal, gastric, gallbladder, hepatic, mammary, ovarian, endometrial, head and neck, pulmonary, prostatic, thyroidal, oral, ocular, nasopharyngeal, endocrine, as well as hematopoietic neoplasms.仅用于科研。不用于诊断过程。未经明确授权不得转售。

数据

c-Myc Antibody (AHO0052)Molecular and cellular biology 2010 -Published figure using c-Myc monoclonal antibody (Product # AHO0052)

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参考文献：

1 Molecular medicine reportsHuman cytomegalovirus UL141 protein interacts with CELF5 and affects viral DNA replication.2 OncogeneLRIG1 opposes epithelial-to-mesenchymal transition and inhibits invasion of basal-like breast cancer cells.3 BMC cell biologyAuxin-inducible protein depletion system in fission yeast.4 Molecular and cellular biologyNovel functional residues in the core domain of histone H2B regulate yeast gene expression and silencing and affect the response to DNA damage.5 GeneticsGenetic and genomewide analysis of simultaneous mutations in acetylated and methylated lysine residues in histone H3 in Saccharomyces cerevisiae.

技术参数

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