p21 Polyclonal Antibody/p21多克隆抗体

货号：PA1-30399

规格：1 mL

价格：6287

产品类型：免疫组化一抗

品牌：Thermo Fisher

抗原：Synthetic peptide (Human) (C terminal).

物种：人/小鼠/大鼠

宿主：兔

抗体亚型：IgG

荧光染料：其它

类型:	多抗	同型对照：
浓度：	0.2 mg/mL	用法：	Assay Dependent(IHC (F))；Assay dependent(IP)；Assay dependent(WB)

产品详细信息Recommended positive controls: C32.靶标信息Protein p21 is a tumor suppressor protein which is an inhibitor of Cyclin-dependent kinases (CDK) and is transcriptionally activated by p53. P21 is important in the response of cells to genotoxic stress and a major transcriptional target of p53 protein. The occurrence of p21 in the nucleus executes binding and inhibition activity of cyclin dependent kinases Cdk1 and Cdk2, and blocks the transition from G1 phase into S phase or from G2 phase into mitosis after DNA damage, which enables the repairof damaged DNA. In the cytoplasm, p21 protein has an anti-apoptotic effect. P21 is able to bind to and inhibit caspase 3, as well as the apoptotic kinases ASK1 and JNK. P21 exhibits a dual function in carcinogenesis, and acts as a tumor suppressor, prevents apoptosis, and acts as an oncogene.仅用于科研。不用于诊断过程。未经明确授权不得转售。

数据

p21 Antibody (PA1-30399) in WBWestern blot of p21/Cip1 in 15 µg of (A) A431 lysate (B) HL-60 lysate and (C) Hela lysate using a p21/Cip1 polyclonal antibody (Product # PA1-30399) at a dilution of '1:200. p21 Antibody (PA1-30399)IP-MS enrichment of P21 (LFQ intensity): P21 was enriched 3902-fold from HCT116 lysate compared to background proteins, using the optimized IP-MS workflow with Pierce MS-Compatible Magnetic IP Kit protein A/G (Product # 90409) and P21 antibody (Product # PA1-30399). The STRING database (www.string-db.org) was used to identify the protein interactor list. See more information on IP-MS verification of antibody selectivity.

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参考文献：

1 BiogerontologyIL-6 deficiency attenuates p53 protein accumulation in aged malemouse hippocampus.

技术参数

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