Thermo CD8b Monoclonal Antibody (eBioH35-17.2 (H35-17.2)), eFluor 450,CD8b Monoclonal Antibody (eBioH35-17.2 (H35-17.2)), eFlu-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

Thermo CD8b Monoclonal Antibody (eBioH35-17.2 (H35-17.2)), eFluor 450,CD8b Monoclonal Antibody (eBioH35-17.2 (H35-17.2)), eFlu

2024-10-24

CD8b Monoclonal Antibody (eBioH35-17.2 (H35-17.2)), eFluor 450

货号：48-0083-82

规格：100μg

价格：2844

产品类型：流式抗体

品牌：Thermo Fisher

物种：小鼠

宿主：大鼠

抗体亚型：IgG2b, kappa

荧光染料：eFluor 450

抗体类型	单抗	同型对照：	Rat IgG2b kappa Isotype Control (eB149/10H5), eFluor 450
浓度：	0.2 mg/mL	用法：	0.25 μg/test (Flow)
产品详细信息Description: The eBioH35-17.2 monoclonal antibody reacts with the mouse CD8 beta molecule. The CD8 beta chain associates with the CD8 alpha chain to form the CD8 alpha/beta heterodimer expressed on the surface of a majority of thymocytes, and on peripheral cytotoxic alpha beta TCR T cells. CD8 binds to MHC class I and plays a role in T cell development and activation of mature T cells.Applications Reported: This H35-17.2 antibody has been reported for use in flow cytometric analysis.靶标信息The CD8B antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 beta chain isoforms. Multiple alternatively spliced transcript variants encoding distinct membrane associated or secreted isoforms have been described. A pseudogene, also located on chromosome 2, has been identified.
数据
CD8b Antibody (48-0083-82) in FlowStaining of C57Bl/6 splenocytes with Anti-Mouse CD8a FITC (Product # 11-0081-82) and 0.125 µg of Rat IgG2b K Isotype Control eFluor® 450 (Product # 48-4031-82) (left) or 0.125 µg of Anti-Mouse CD8b eFluor® 450 (right). Total viable cells were used for analysis.
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参考文献：
1.Nature communicationsIntratumoral modulation of the inducible co-stimulator ICOS by recombinant oncolytic virus promotes systemic anti-tumour immunity."Published figure using CD8b monoclonal antibody (Product # 48-0083-82) in Flow Cytometry"2.Nature medicineInflammasome-independent role of AIM2 in suppressing colon tumorigenesis via DNA-PK and Akt."48-0083 was used in Flow cytometry/Cell sorting to show AIM2 regulates colon tumorigenesis by reducing activation of both DNA-PK and Akt, suggesting that Akt inhibitors could be used in treatment of certain cancers."AuthorsWilson JE,Petrucelli AS,Chen L,Koblansky AA,Truax AD,Oyama Y,Rogers AB,Brickey WJ,Wang Y,Schneider M,Mühlbauer M,Chou WC,Barker BR,Jobin C,Allbritton NL,Ramsden DA,Davis BK,Ting JP3.Nature communicationsMetastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression."Published figure using CD8b monoclonal antibody (Product # 48-0083-82) in Flow Cytometry"4.PloS oneDeletion of Snai2 and Snai3 results in impaired physical development compounded by lymphocyte deficiency."Published figure using CD8b monoclonal antibody (Product # 48-0083-82) in Flow Cytometry"5.GastroenterologyExpression of the chemokine binding protein M3 promotes marked changes in the accumulation of specific leukocytes subsets within the intestine."Published figure using CD8b monoclonal antibody (Product # 48-0083-82) in Flow Cytometry"

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Thermo CD8b Monoclonal Antibody (eBioH35-17.2 (H35-17.2)), eFluor 450,CD8b Monoclonal Antibody (eBioH35-17.2 (H35-17.2)), eFlu

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