Thermo CD39 Monoclonal Antibody (24DMS1), eFluor 660,CD39 Monoclonal Antibody (24DMS1), eFluor 660-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

Thermo CD39 Monoclonal Antibody (24DMS1), eFluor 660,CD39 Monoclonal Antibody (24DMS1), eFluor 660

2024-10-24

CD39 Monoclonal Antibody (24DMS1), eFluor 660

货号：50-0391-80,50-0391-82

规格：25μg,100μg

价格：1267,3163

产品类型：流式抗体

品牌：Thermo Fisher

物种：小鼠

宿主：大鼠

抗体亚型：IgG2b, kappa

荧光染料：eFluor 660

抗体类型	单抗	同型对照：	Rat IgG2b kappa Isotype Control (eB149/10H5), eFluor 660
浓度：	0.2 mg/mL	用法：	0.125 μg/test (Flow)
产品详细信息Description: The 24DMS1 monoclonal antibody reacts with mouse CD39, also known as NTPDaseI. E-NTPDases are enzymes that convert nucleoside tri- and diphosphates (NTDPs) into nucleoside monophosphate (NMP), thereby removing toxic extracellular ATP and ADP. CD39 is the dominant member of this family in the immune system and is involved in suppression of inflammation and control of platelet activation. CD39 can impact expression of CD73, another E-NTPase. Together, these molecules influence inflammation responses. CD39 is expressed on B cells, Langerhans cells and most monocytes. In addition, CD39 is found on a subset of CD4+ T cells that are mostly CD25+FoxP3+ T reg cells. T reg cells from CD39-null mice showed impaired suppressive properties in vitro and in vivo.Applications Reported: This 24DMS1 antibody has been reported for use in flow cytometric analysis.Applications Tested: This 24DMS1 antibody has been tested by flow cytometric analysis of mouse splenocytes. This can be used at less than or equal to 0.125 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.eFluor® 660 is a replacement for Alexa Fluor® 647. eFluor® 660 emits at 659 nm and is excited with the red laser (633 nm). Please make sure that your instrument is capable of detecting this fluorochome.Excitation: 633-647 nm; Emission: 668 nm; Laser: Red Laser.Filtration: 0.2 µm post-manufacturing filtered.靶标信息CD39 cell surface antigen is a 70-100kD molecule expressed on peripheral blood B cells, monocytes, T cell clones, and also weakly expressed on granulocytes. CD39 has intrinsic ecto-ATPase activity. Expression of CD39 is induced on T cells and increased on B cells as a late activation antigen
数据
CD39 Antibody (50-0391-82) in FlowSurface staining of mouse splenocytes with Anti-Mouse CD4 FITC (Product # 11-0041-82) and 0.06 µg of Anti-Mouse CD39 eFluor® 660, followed by intracellular staining with Anti-Mouse Foxp3 PE (Product # 12-5773-82) using the Foxp3 Staining Buffer Set (Product # 00-5523-00). The histogram (right) demonstrates staining of Anti-Mouse CD39 on CD4+Foxp3. cells (orange histogram) and CD4+Foxp3+ cells (purple histogram) as gated in the dot plot (left).
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参考文献：
1.Frontiers in immunologyToll-Like Receptor-Mediated Activation of CD39 Internalization in BMDCs Leads to Extracellular ATP Accumulation and Facilitates P2X7 Receptor Activation."Published figure using CD39 monoclonal antibody (Product # 50-0391-82) in Flow Cytometry"2.Frontiers in immunologyLimited Foxp3+Regulatory T Cells Response During AcuteTrypanosoma cruziInfection Is Required to Allow the Emergence of Robust Parasite-Specific CD8+T Cell Immunity."50-0391 was used in Flow cytometry/Cell sorting to study the role of regulatory T cells during Trypanosoma cruzi infection."AuthorsAraujo Furlan CL,Tosello Boari J,Rodriguez C,Canale FP,Fiocca Vernengo F,Boccardo S,Beccaria CG,Adoue V,Joffre O,Gruppi A,Montes CL,Acosta Rodriguez EV3.Purinergic signallingSelective deletion of ENTPD1/CD39 in macrophages exacerbates biliary fibrosis in a mouse model of sclerosing cholangitis."Published figure using CD39 monoclonal antibody (Product # 50-0391-82) in Flow Cytometry"4.Cell stem cellCD150highBone Marrow Tregs Maintain Hematopoietic Stem Cell Quiescence and Immune Privilege via Adenosine."Published figure using CD39 monoclonal antibody (Product # 50-0391-82) in Flow Cytometry"5.Nature neuroscienceDifferentiation of human and murine induced pluripotent stem cells to microglia-like cells."Published figure using CD39 monoclonal antibody (Product # 50-0391-82) in Flow Cytometry"

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Thermo CD39 Monoclonal Antibody (24DMS1), eFluor 660,CD39 Monoclonal Antibody (24DMS1), eFluor 660

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