Thermo 11-9818-42 CD303a Monoclonal Antibody (201A), FITC,CD303a Monoclonal Antibody (201A), FITC

2024-10-24

CD303a Monoclonal Antibody (201A), FITC

货号:11-9818-42

规格:100 Tests

价格:3090

产品类型:流式抗体

品牌:Thermo Fisher

物种:人

宿主:小鼠

抗体亚型:IgG2a, kappa

荧光染料:FITC

抗体类型 单抗同型对照:Mouse IgG2a kappa Isotype Control (eBM2a), FITC
浓度:5 µL/Test用法:5 µL (0.125 µg)/test(Flow)
产品详细信息Description: This 201A monoclonal antibody reacts with human CD303a, which is also known as CLEC4C or Blood Dendritic Cell Antigen 2 (BDCA-2). This type II transmembrane protein is expressed almost exclusively on plasmacytoid dendritic cells, which secrete type I interferon during antiviral and antitumor responses. Studies have demonstrated that CD303a binds asialo-galactosyl-oligosaccharides on invading pathogens, resulting in the activation of signaling pathways that lead to CD303a internalization and downregulation of interferon production.Applications Reported: This 201A antibody has been reported for use in flow cytometric analysis.Applications Tested: This 201A antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood. This can be used at 5 µL (0.125 µg) per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test.Excitation: 488 nm; Emission: 520 nm; Laser: Blue Laser.Filtration: 0.2 µm post-manufacturing filtered.靶标信息This gene encodes a member of the C-type lectin/C-type lectin-like domain superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may play a role in dendritic cell function. Two transcript variants encoding distinct isoforms have been identified for this gene.
数据
CD303a Antibody (11-9818-42) in FlowStaining of normal human peripheral blood cells with Anti-Human CD123 APC (Product # 17-1239-42) and Mouse IgG2a K Isotype Control FITC (Product # 11-4724-42) (left) or Anti-Human CD303a FITC (right). Cells in the monocyte gate were used for analysis.
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参考文献:
1.OncotargetPeripheral kynurenine/tryptophan ratio is not a reliable marker of systemic indoleamine 2,3-dioxygenase: A lesson drawn from patients on hemodialysis."11-9818 was used in Flow cytometry/Cell sorting to evaluate the clinical value of using the plasma kynurenine/tryptophan ratio to estimate cell-mediated immune responses to tuberculin skin testing and risk of new bacterial infection."AuthorsChen Y,Xie Z,Xiao C,Zhang M,Li Z,Xie J,Zhang Y,Zhao X,Zeng P,Mo L,Liang X,Shi W2.PLoS pathogensMalaria-induced NLRP12/NLRP3-dependent caspase-1 activation mediates inflammation and hypersensitivity to bacterial superinfection."11-9818 was used in Flow cytometry/Cell sorting to demonstrate that NLRP12/NLRP3-dependent activation of caspase-1 is likely to be a key event in mediating systemic production of IL-1β."AuthorsAtaide MA,Andrade WA,Zamboni DS,Wang D,Souza Mdo C,Franklin BS,Elian S,Martins FS,Pereira D,Reed G,Fitzgerald KA,Golenbock DT,Gazzinelli RT3.Journal of virologyRespiratory syncytial virus G protein CX3C motif impairs human airway epithelial and immune cell responses."11-9818 was used in Flow cytometry/Cell sorting to elucidate the contribution of a conserved motif in the RSV G protein to the pathogenesis of the disease."AuthorsChirkova T,Boyoglu-Barnum S,Gaston KA,Malik FM,Trau SP,Oomens AG,Anderson LJ
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