Thermo 12-0149-41 CD14 Monoclonal Antibody (61D3), PE,CD14 Monoclonal Antibody (61D3), PE-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

Thermo 12-0149-41 CD14 Monoclonal Antibody (61D3), PE,CD14 Monoclonal Antibody (61D3), PE

2024-10-24

CD14 Monoclonal Antibody (61D3), PE

货号：12-0149-41,12-0149-42

规格：25 Tests,100 Tests

价格：1112,2490

产品类型：流式抗体

品牌：Thermo Fisher

物种：人

宿主：小鼠

抗体亚型：IgG1, kappa

荧光染料：PE

抗体类型	单抗	同型对照：	Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), PE
浓度：	5 µL/Test	用法：	5 µL (0.5 µg)/test(Flow)
产品详细信息Description: The 61D3 monoclonal antibody reacts with human CD14, a 53-55 kDa GPI-linked glycoprotein. CD14 is expressed on monocytes, interfollicular macrophages and some dendritic cells. Complexes of LPS and LBP (LPS-Binding Protein) bind with high affinity to monocytes through the surface CD14.Applications Reported: The 61D3 antibody has been reported for use in flow cytometric analysis.Applications Tested: This 61D3 antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at 5 µL (0.5 µg) per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test.Excitation: 488-561 nm; Emission: 578 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser.Filtration: 0.2 µm post-manufacturing filtered.靶标信息CD14 is a 55 kDa GPI-anchored glycoprotein that is constitutively expressed on the surface of mature monocytes, macrophages, and neutrophils. CD14 also serves as a multifunctional lipopolysaccharide receptor, and is released to the serum both as a secreted and enzymatically cleaved GPI-anchored form. CD14 binds lipopolysaccharide molecule in a reaction catalyzed by lipopolysaccharide-binding protein (LBP), an acute phase serum protein. The soluble sCD14 can discriminate slight structural differences between lipopolysaccharides and is important for neutralization of serum allochthonous lipopolysaccharides by reconstituted lipoprotein particles. Further, CD14 has been shown to bind apoptotic cells, and can affect allergic, inflammatory and infectious processes. Alternative splicing results in multiple transcript variants encoding the same CD14 isoform. Diseases associated with CD14 dysfunction include mycobacterium chelonae infection and Croup.
数据
CD14 Antibody (12-0149-42) in FlowStaining of normal human peripheral blood cells with Mouse IgG1 K Isotype Control PE (Product # 12-4714-81) (blue histogram) or Anti-Human CD14 PE (purple histogram). Cells in the monocyte gate were used for analysis.
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参考文献：
1.Inflammation and regenerationEffects of acute exposure to low-dose radiation on the characteristics of human bone marrow mesenchymal stromal/stem cells."12-0149 was used in Flow cytometry/Cell sorting to determine whether low dose irradiation affects the function of mesenchymal stromal/stem cells."AuthorsFujishiro A,Miura Y,Iwasa M,Fujii S,Sugino N,Andoh A,Hirai H,Maekawa T,Ichinohe T2.PLoS pathogensCross-talk between microglia and neurons regulates HIV latency."12-0149 was used in Flow cytometry/Cell sorting to demonstrate that the cross-talk between healthy neurons and microglia modulates HIV expression, while HIV expression impairs this intrinsic molecular mechanism resulting in the excessive and uncontrolled stimulation of microglia-mediated neurotoxicity."AuthorsAlvarez-Carbonell D,Ye F,Ramanath N,Garcia-Mesa Y,Knapp PE,Hauser KF,Karn J3.Molecular medicine reportsNLRP3 inflammasome expression in peripheral blood monocytes of coronary heart disease patients and its modulation by rosuvastatin."Published figure using CD14 monoclonal antibody (Product # 12-0149-42) in Flow Cytometry"4.PLoS pathogensCross-talk between microglia and neurons regulates HIV latency."12-0149 was used in Flow cytometry/Cell sorting to demonstrate that the cross-talk between healthy neurons and microglia modulates HIV expression, while HIV expression impairs this intrinsic molecular mechanism resulting in the excessive and uncontrolled stimulation of microglia-mediated neurotoxicity."AuthorsAlvarez-Carbonell D,Ye F,Ramanath N,Garcia-Mesa Y,Knapp PE,Hauser KF,Karn J5.Nature communicationsCellular metabolism constrains innate immune responses in early human ontogeny."Published figure using CD14 monoclonal antibody (Product # 12-0149-42) in Flow Cytometry"

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Thermo 12-0149-41 CD14 Monoclonal Antibody (61D3), PE,CD14 Monoclonal Antibody (61D3), PE

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