HLA-DR Monoclonal Antibody (LN3), Alexa Fluor 700 Thermo HLA-DR Monoclonal Antibody (LN3), Alexa Fluor 700-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

HLA-DR Monoclonal Antibody (LN3), Alexa Fluor 700 Thermo HLA-DR Monoclonal Antibody (LN3), Alexa Fluor 700

2024-10-28

HLA-DR Monoclonal Antibody (LN3), Alexa Fluor 700

货号：56-9956-41,56-9956-42

规格：25 Tests,100 Tests

市场价格：1545,3163

产品类型：流式抗体

品牌：Thermo Fisher

物种：人

宿主：小鼠

抗体亚型：IgG2b, kappa

荧光染料：Alexa Fluor 700

抗体类型	一抗	同型对照：	Mouse IgG2b kappa Isotype Control (eBMG2b), Alexa Fluor 700
浓度：	5 µL/Test	用法：	5 μL (0.01 μg)/test (Flow)
产品详细信息Description: The LN3 mAb reacts with the human major histocompatibility complex (MHC) class II, HLA-DR. HLA-DR is expressed on the surface of human antigen presenting cells (APC) including B cells, monocytes, macrophages, DCs, and activated T cells. HLA-DR is a heterodimeric transmembrane protein composed of alpha and beta subunits and plays an important role in the presentation of peptides to CD4^+ T lymphocytes.Applications Reported: This LN3 antibody has been reported for use in flowcytometric analysis.Applications Tested: This LN3 antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at 5 µL (0.01 µg) per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test.Alexa Fluor® 700 emits at 723 nm and can be excited with the red laser (633 nm). Most instruments will require a 685 LP mirror and 710/20 filter. Please make sure that your instrument is capable of detecting this fluorochrome.Excitation: 633-647 nm; Emission: 723 nm; Laser: Red Laser.Filtration: 0.2 µm post-manufacturing filtered.靶标信息HLA-DR, like other MHC class II molecules, is a transmembrane glycoprotein composed of a 36 kDa alpha chain (DRA) and 27 kDa beta chain (DRB). The alpha chain gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5. Within the DR molecule the beta chaincontains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. HLA-DR is expressed primarily on antigen presenting cells such as B lymphocytes, monocytes, macrophages, thymic epithelial cells and activated T lymphocytes. Three loci, DR, DQ and DP, encode the major expressed products of the human class II region. The human MHC class II molecules bind intracellularly processed peptides, present them to T-helper cells, and have a critical role in the initiation of the immune response.
数据
HLA-DR Antibody (56-9956-41) in FlowNormal human peripheral blood cells were stained with Mouse IgG2b kappa Isotype Control, Alexa Fluor 700 (Product # 56-4732-80) (blue histogram) or HLA-DR Monoclonal Antibody, Alexa Fluor 700 (purple histogram). Cells in the lymphocyte gate (left) or monocyte gate (right) were used for analysis.
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参考文献：
1.Frontiers in molecular neuroscienceIncreased White Matter Inflammation in Aging- and Alzheimer's Disease Brain."Published figure using HLA-DR monoclonal antibody (Product # 56-9956-42) in Immunohistochemistry"2.Nature communicationsExpression of CD20 after viral reactivation renders HIV-reservoir cells susceptible to Rituximab."Published figure using HLA-DR monoclonal antibody (Product # 56-9956-42) in Flow Cytometry"3.Cell reportsLarge-Scale Human Dendritic Cell Differentiation Revealing Notch-Dependent Lineage Bifurcation and Heterogeneity."Published figure using HLA-DR monoclonal antibody (Product # 56-9956-42) in Flow Cytometry"4.Biology openHigh-yield isolation of menstrual blood-derived endometrial stem cells by direct red blood cell lysis treatment."Published figure using HLA-DR monoclonal antibody (Product # 56-9956-42) in Flow Cytometry"5.Stem cell reportsLack of T Cell Response to iPSC-Derived Retinal Pigment Epithelial Cells from HLA Homozygous Donors."Published figure using HLA-DR monoclonal antibody (Product # 56-9956-42) in ELISA"

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