CD62L (L-Selectin) Monoclonal Antibody (DREG-56 (DREG56)), eFluor 450, eBioscience

货号：48-0629-42,48-0629-41

规格：100 Tests,25 Tests

市场价格：2271,925

产品类型：流式抗体

品牌：eBioscience

抗原：CD62L

物种：人

宿主：小鼠

抗体亚型：IgG1, kappa

克隆号：DREG-56 (DREG56)

荧光染料：eFluor 450

类型:	一抗	同型对照：	Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), eFluor 450, eBioscience
浓度：	5 µL/Test	用法：	5 µL (0.25 µg)/test（Flow）

产品详细信息Description: The DREG-56 monoclonal antibody reacts with human CD62L, a 76 kDa member of the selectin family. CD62L is expressed by neutrophils, monocytes, and subsets of T, B, and NK cells and binds a number of glycosylated, fucosylated, sulfated sialylated glycoproteins including CD34, glycam-1 and MAdCAM-1. These interactions mediate rolling of lymphocytes on activated endothelium at the sites of inflammation and homing of cells to the high endothelial venules (HEV) of peripheral lymphoid tissues.Applications Reported: This DREG-56 (DREG56) antibody has been reported for use in flow cytometric analysis.Applications Tested: This DREG-56 (DREG56) antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at 5 µL (0.25 µg) per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test.eFluor® 450 is an alternative to Pacific Blue®. eFluor® 450 emits at 445 nm and is excited with the Violet laser (405 nm). Please make sure that your instrument is capable of detecting this fluorochome.Excitation: 405 nm; Emission: 445 nm; Laser: Violet Laser.Filtration: 0.2 µm post-manufacturing filtered.靶标信息The human CD62L is a 74-95 kDa glycoprotein member of the selectin family of adhesion receptors. L-Selectin is comprised of an aminoterminal C-type lectin binding domain, an epidermal growth factor-like domain, two short consensus repeat (SCR) sequences homologous to those found in complement binding proteins, a short spacer region, a transmembrane region and a short cytoplasmic region. Human CD62L (L-Selectin) is constitutively expressed on all classes of leukocytes including lymphocytes (except a substantial population of memory T cells), monocytes and polymorphonuclear cells.仅用于科研。不用于诊断过程。

数据

CD62L (L-Selectin) Antibody (48-0629-42) in FlowStaining of normal human peripheral blood cells with Anti-Human CD4 APC (Product # 17-0049-42) and Mouse IgG1 K Isotype Control eFluor® 450 (Product # 48-4714-82) (left) or Anti-Human CD62L (L-Selectin) eFluor® 450 (right). Cells in the lymphocyte gate were used for analysis.

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参考文献：

1.European journal of immunologyTyrosine kinase 2 is not limiting human antiviral type III interferon responses."48-0629 was used in Flow cytometry/Cell sorting to analyse the role of tyrosine kinase 2 in type-III interferon mediated responses and natural killer-cell function."AuthorsFuchs S,Kaiser-Labusch P,Bank J,Ammann S,Kolb-Kokocinski A,Edelbusch C,Omran H,Ehl S2.Nature communicationsHeterogeneity of human bone marrow and blood natural killer cells defined by single-cell transcriptome."Published figure using CD62L (L-Selectin) monoclonal antibody (Product # 48-0629-42) in Flow Cytometry"3.Molecular medicine reportsn-butanol extract from Foliumisatidis inhibits the lipopolysaccharide-induced downregulation of CXCR1 and CXCR2 on human neutrophils."Published figure using CD62L (L-Selectin) monoclonal antibody (Product # 48-0629-42) in Flow Cytometry"4.European journal of immunologyTyrosine kinase 2 is not limiting human antiviral type III interferon responses."48-0629 was used in Flow cytometry/Cell sorting to analyse the role of tyrosine kinase 2 in type-III interferon mediated responses and natural killer-cell function."AuthorsFuchs S,Kaiser-Labusch P,Bank J,Ammann S,Kolb-Kokocinski A,Edelbusch C,Omran H,Ehl S

技术参数

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