CD16 Monoclonal Antibody (B73.1), PE,

货号：12-0167-41,12-0167-42

规格：25 Tests,100Tests

市场价格：0,2657

产品类型：流式抗体

品牌：eBioscience

抗原：CD16

物种：人

宿主：小鼠

抗体亚型：IgG1, kappa

克隆号：B73.1

荧光染料：PE

类型:	单抗	同型对照：	Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), PE,
浓度：	5 µL/Test	用法：	5 µL (0.5 µg)/test(Flow)

产品详细信息Description: This B73.1 monoclonal antibody reacts with human CD16, a member of the Fc receptor family also known as Fc gamma RIIIa and Fc gamma RIIIb. This 50-65 kDa receptor is expressed on natural killer cells, neutrophils, monocytes, and macrophages. Crosslinking of CD16 in natural killer cells and monocytes results in activation of the MAPK and PI3K signaling pathways, thus regulating the production of TNF alpha, IL-6, and IL-1 beta.This monoclonal antibody has been shown to block Fc receptor functions.Applications Reported: This B73.1 (B73.1.1) antibody has been reported for use in flow cytometric analysis.Applications Tested: This B73.1 (B73.1.1) antibody has been pre-titrated and tested by flow cytometric analysis of normal peripheral blood cells. This can be used at 5 µL (0.5 µg) per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test.Excitation: 488-561 nm; Emission: 578 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser.Filtration: 0.2 µm post-manufacturing filtered.靶标信息CD16 (FCGR3A) is a 50-65 kDa cell surface molecule that exists in two forms - a transmembranous form expressed by NK cells and some T cells, and a phosphatidylinositol linked form expressed by granulocytes. CD16 is a low affinity receptor for IgG (FcR III), and is an important receptor mediating ADCC by NK cells. Human CD16 is expressed in two forms FCGR3A and FCGR3B. FCGR3A is associated with the FcepsilonRI-gamma subunit and is responsible for antibody-dependent NK cell cytotoxicity. Mast cell FCGR3A is associated, with FcepsilonRI-beta subunit. Besides IgG, FCGR3A can be triggered also by oligomeric IgE. FCGR3B is a GPI-linked monomeric receptor expressed on neutrophils and is involved in their activation and induction of a pro-adhesive phenotype. Diseases associated with CD16 dysfunction include immunodeficiency 20 and systemic lupus erythematosus.

数据

CD16 Antibody (12-0167-41) in FlowStaining of normal human peripheral blood cells with Anti-Human CD56 (NCAM) APC and Mouse IgG1 kappa Isotype Control PE (Product # 12-4714-81) (left) or Anti-Human CD16 PE (right). Cells in the granulocyte gate were used for analysis.

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参考文献

1. Cell death & diseaseThe pro-inflammatory phenotype of the human non-classical monocyte subset is attributed to senescence.2. PLoS pathogensPhosphoantigen/IL2 expansion and differentiation of Vγ2Vδ2 T cells increase resistance to tuberculosis in nonhuman primates.3. Nature medicineDKK2 imparts tumor immunity evasion through β-catenin-independent suppression of cytotoxic immune-cell activation.4. Journal of neurovirologyImmortalization of primary microglia: a new platform to study HIV regulation in the central nervous system.5. PLoS neglected tropical diseasesCytoplasmic Localization of HTLV-1 HBZ Protein: A Biomarker of HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP).

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