CD23 Monoclonal Antibody (B3B4), Biotin, eBioscience
货号:13-0232-81
规格:50 µg
市场价格:822
产品类型:流式抗体
品牌:eBioscience
抗原:CD23
物种:小鼠
宿主:大鼠
抗体亚型:IgG2a, kappa
克隆号:B3B4
荧光染料:Biotin
类型: | 流式抗体 | 同型对照: | Rat IgG2a kappa Isotype Control (eBR2a), Biotin, eBioscience |
浓度: | 0.5 mg/mL | 用法: | 0.25 μg/test(Flow) |
产品详细信息Description:
The B3B4 monoclonal antibody reacts with mouse CD23, a 45 kDa type II transmembrane glycoprotein. CD23 is expressed on resting conventional B cells, and its expression is modulated upon B-cell activation. B-1 cell lineage (CD5+ B cells) does not express CD23. Soluble forms of the antigen have been reported to be biologically active. CD23 is a low affinity receptor for IgE and is thought to play a role in the regulation of IgE response and B-cell activation. CD21 is thought to bind to CD23.Applications Reported: The B3B4 antibody has been reported for use in flow cytometric analysis.Applications Tested: The B3B4 antibody has been tested by flow cytometric analysis of mouse splenocytes. This can be used at less than or equal to 0.25 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Filtration: 0.2 µm post-manufacturing filtered.
靶标信息
CD23 is a 45 kDa glycoprotein which is present on a subpopulation of freshly isolated peripheral blood and tonsil B cells and strongly expressed on EBV-transformed B lymphoblasts. The CD23 molecule is identical to the low affinity IgE receptor found on B cells. Expression of CD23 has been detected in neoplastic cells from cases of B cell chronic lymphocyctic leukaemia and some cases of centroblastic/centrocytic lymphoma. CD23 is present on a subpopulation of freshly isolated peripheral blood andtonsil B cells and strongly expressed on EBV-transformed B lymphoblasts. Functionally, CD23 is involved in B cell growth and differentiation, and IgE production. Further, CD23 has a soluble form that is a potent mitogenic factor. Diseases associated with CD23 dysfunction include chronic conjunctivitis and chronic lymphocytic leukemia.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
数据 |
CD23 Antibody (13-0232-81) in FlowSurface staining of mouse splenocytes with Anti-Human/Mouse CD45R (B220) PE (Product # 12-0452-82) and Anti-Mouse CD23 FITC. Total viable cells were used for analysis. |
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参考文献: |
1.International immunologyThymic stromal lymphopoietin (TSLP)-induced polyclonal B-cell activation and autoimmunity are mediated by CD4+ T cells and IL-4."13-0232 was used in Flow cytometry/Cell sorting to demonstrate that thymic stromal lymphopoietin levels are an important factor in B-cell homeostasis and humoral autoimmunity."2.Journal of immunology (Baltimore, Md. : 1950)Natural IgM is produced by CD5- plasma cells that occupy a distinct survival niche in bone marrow."13-0232 was used in Flow cytometry/Cell sorting to investigate the origin of natural IgM, showing that it is produced by CD5- plasma cells that occupy a distinct survival niche in bone marrow."3.Journal of immunology (Baltimore, Md. : 1950)Dendritic cell-specific ablation of the protein tyrosine phosphatase Shp1 promotes Th1 cell differentiation and induces autoimmunity."13-0232 was used in Flow cytometry/Cell sorting to investigate the molecules that regulate dendritic cells to protect against autoimmunity, showing that loss of Shp1 promotes Th1 cell differentiation and induces autoimmunity." |
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