CD23 Monoclonal Antibody (B3B4), Biotin, eBioscience eBioscience 小鼠CD23单克隆抗体Biotin

2024-10-28

CD23 Monoclonal Antibody (B3B4), Biotin, eBioscience

货号:13-0232-81

规格:50 µg

市场价格:822

产品类型:流式抗体

品牌:eBioscience

抗原:CD23

物种:小鼠

宿主:大鼠

抗体亚型:IgG2a, kappa

克隆号:B3B4

荧光染料:Biotin

类型: 流式抗体同型对照:Rat IgG2a kappa Isotype Control (eBR2a), Biotin, eBioscience
浓度: 0.5 mg/mL用法:0.25 μg/test(Flow)
产品详细信息Description:

The B3B4 monoclonal antibody reacts with mouse CD23, a 45 kDa type II transmembrane glycoprotein. CD23 is expressed on resting conventional B cells, and its expression is modulated upon B-cell activation. B-1 cell lineage (CD5+ B cells) does not express CD23. Soluble forms of the antigen have been reported to be biologically active. CD23 is a low affinity receptor for IgE and is thought to play a role in the regulation of IgE response and B-cell activation. CD21 is thought to bind to CD23.Applications Reported: The B3B4 antibody has been reported for use in flow cytometric analysis.Applications Tested: The B3B4 antibody has been tested by flow cytometric analysis of mouse splenocytes. This can be used at less than or equal to 0.25 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Filtration: 0.2 µm post-manufacturing filtered.

靶标信息

CD23 is a 45 kDa glycoprotein which is present on a subpopulation of freshly isolated peripheral blood and tonsil B cells and strongly expressed on EBV-transformed B lymphoblasts. The CD23 molecule is identical to the low affinity IgE receptor found on B cells. Expression of CD23 has been detected in neoplastic cells from cases of B cell chronic lymphocyctic leukaemia and some cases of centroblastic/centrocytic lymphoma. CD23 is present on a subpopulation of freshly isolated peripheral blood andtonsil B cells and strongly expressed on EBV-transformed B lymphoblasts. Functionally, CD23 is involved in B cell growth and differentiation, and IgE production. Further, CD23 has a soluble form that is a potent mitogenic factor. Diseases associated with CD23 dysfunction include chronic conjunctivitis and chronic lymphocytic leukemia.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

数据
CD23 Antibody (13-0232-81) in FlowSurface staining of mouse splenocytes with Anti-Human/Mouse CD45R (B220) PE (Product # 12-0452-82) and Anti-Mouse CD23 FITC. Total viable cells were used for analysis.
推荐产品:
二抗荧光二抗免疫组化一抗标签抗体
参考文献:

1.International immunologyThymic stromal lymphopoietin (TSLP)-induced polyclonal B-cell activation and autoimmunity are mediated by CD4+ T cells and IL-4."13-0232 was used in Flow cytometry/Cell sorting to demonstrate that thymic stromal lymphopoietin levels are an important factor in B-cell homeostasis and humoral autoimmunity."2.Journal of immunology (Baltimore, Md. : 1950)Natural IgM is produced by CD5- plasma cells that occupy a distinct survival niche in bone marrow."13-0232 was used in Flow cytometry/Cell sorting to investigate the origin of natural IgM, showing that it is produced by CD5- plasma cells that occupy a distinct survival niche in bone marrow."3.Journal of immunology (Baltimore, Md. : 1950)Dendritic cell-specific ablation of the protein tyrosine phosphatase Shp1 promotes Th1 cell differentiation and induces autoimmunity."13-0232 was used in Flow cytometry/Cell sorting to investigate the molecules that regulate dendritic cells to protect against autoimmunity, showing that loss of Shp1 promotes Th1 cell differentiation and induces autoimmunity."

技术参数
© bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪是专业的授权总代理区域代理经销平台。
© 如需询价,请加客服QQ:1749072012 、客服微信:jinshanbio,或发送邮件到1749072012@qq.com
© 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务,数据资源基于CC协议。
© 本文地址:https://gibcohyclone.cn/thread-48963.htm
产品询价需求提交
返回
扫码添加客服微信,咨询产品报价