Rabbit anti Human PRKAR2A antibody 伯乐 PRKAR2A 抗体 人VPA00905

2024-10-28

Rabbit anti Human PRKAR2A antibody

货号:VPA00905

规格:100 µl

市场价格:2746

产品类型:免疫组化一抗

品牌:Bio-Rad

抗原:PRKAR2A

物种:人

宿主:兔

抗体亚型:IgG

荧光染料:Purified

产品介绍
Rabbit anti Human PRKAR2A antibodyrecognizes the PRKAR2A, also known as cAMP-dependent protein kinase regulatory subunit RII alpha and cAMP-dependent protein kinase type II-alpha regulatory subunit.cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by PRKAR2A is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. It may interact with various A-kinase anchoring proteins and determine the subcellular localization of cAMP-dependent protein kinase. This subunit has been shown to regulate protein transport from endosomes to the Golgi apparatus and further to the endoplasmic reticulum (ER) (provided by RefSeq, Jul 2008).Rabbit anti Human PRKAR2A antibody detects a band of 50 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
产品详情
Target SpeciesHuman
Product FormPurified IgG - liquid
PreparationRabbit polyclonal antibody purified by affinity chromatography on immunogen
Buffer SolutionPhosphate buffered saline
Preservative Stabilisers0.09% Sodium Azide<50% Glycerol
ImmunogenRecombinant protein of human PRKAR2A
Approx. Protein ConcentrationsIgG concentration 0.5 mg/ml
AcknowledgementsPrecisionAb is a trademark of Bio-Rad Laboratories
RegulatoryFor research purposes only
Guarantee12 months from date of despatch
存储条件
Store undiluted at -20°C, avoiding repeated freeze thaw cycles
应用
Application NameVerifiedMin DilutionMax Dilution
Western Blotting
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
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技术参数

产品应用 WB

产品类型 多克隆抗体

推荐用于 WB

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