Mouse anti Human CDK4 antibody BIO-RAD VMA00520 Mouse anti Human CDK4 antibody

2024-10-28

Mouse anti Human CDK4 antibody

货号:VMA00520

规格:100μl

市场价格:3655

产品类型:免疫组化一抗

品牌:Bio-Rad

抗原:CDK4

物种:人

宿主:小鼠

抗体亚型:IgG2a

克隆号:1529CT850.162.73

荧光染料:Purified

产品介绍
Mouse anti Human CDK4 antibodyrecognizes the cyclin-dependent kinase 4, also known as cell division protein kinase 4.The protein encoded by CDK4 gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16 (INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in CDK4 as well as in its related proteins including D-type cyclins, p16 (INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of CDK4 have been reported (provided by RefSeq, Jul 2008).Mouse anti Human CDK4 antibody detects a band of 30 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
产品详情
Target SpeciesHuman
Product FormPurified IgG - liquid
PreparationMouse monoclonal antibody purified by affinity chromatography on Protein G from tissue culture supernatant.
Buffer SolutionPhosphate buffered saline
Preservative Stabilisers0.09% Sodium Azide (NaN3).
ImmunogenMouse-derived recombinant protein of human CDK4
AcknowledgementsPrecisionAb is a trademark of Bio-Rad Laboratories.
RegulatoryFor research purposes only
Guarantee12 months from date of despatch.
存储条件
Store undiluted at -20°C, avoiding repeated freeze thaw cycles.
应用
Application NameVerifiedMin DilutionMax Dilution
Western Blotting1/1000
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.Flow CytometryUse 10ul of the suggested working dilution to label 106cells or 100ul human whole blood.
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产品类型 单克隆抗体

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