Rat anti Mouse CD8 alpha: StarBright Violet 440

货号：MCA609SBV440

规格：100 Tests/0.5ml

市场价格：3553

产品类型：流式抗体

品牌：Bio-Rad

抗原：CD8 alpha

物种：小鼠

宿主：大鼠

抗体亚型：IgG2a

克隆号：KT15

荧光染料：StarBright Violet 440

类型:	单抗	同型对照：	IgG2a
浓度：		用法：	5 µL/test(Flow)
免疫原性：	T cell clone, C6

Rat anti mouse CD8α, clone KT15,recognizes thealpha chain of mouse CD8. CD8 is a heterodimeric protein composed of disulphide-linked CD8α andCD8βchains that is expressed primarily on cytotoxic T-cells. CD8 functions in the interaction with MHC Class I-bearing targets and plays a role in T-cell-mediated killing (Nakauchi , H.et al., 1985&Nakauchi, H.et al., 1987).Clone KT15 is reported to block T-cell-mediated cytotoxicity inin vitroassays (Zeis, M.et al., 2002).

数据

Figure A. StarBright Blue 700 conjugated Rat anti Mouse CD3 (MCA500SBB700). Figure B. StarBright Blue 700 conjugated Rat anti Mouse CD3 (MCA500SBB700) and StarBright Violet 440 conjugated Rat anti Mouse CD8a (MCA609SBV440). All experiments performed on red blood cell lysed mouse blood gated on live single cell lymphocytes, in the presence of 10% mouse serum. Data acquired on the ZE5 Cell Analyzer.

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参考文献：

1. Tomonari, K. & Lovering, E. (1988) T-cell receptor-specific monoclonal antibodies against a V beta 11-positive mouse T-cell clone.Immunogenetics. 28 (6): 445-51.2. Whiteland, J.L.et al.(1995) Immunohistochemical detection of T-cell subsets and other leukocytes in paraffin-embedded rat and mouse tissues with monoclonal antibodies.J Histochem Cytochem. 43 (3): 313-20.3. Lee, Y.L.et al(2003) Oral administration of Agaricus blazei (H1 strain) inhibited tumor growth in a sarcoma 180 inoculation model.Exp Anim. 52: 371-5.4. Eller, K.et al.(2011) IL-9 production by regulatory T cells recruits mast cells that are essential for regulatory T cell-induced immune suppression.J Immunol. 186: 83-91.5. Grimm, M.et al.(2010) Evaluation of immunological escape mechanisms in a mouse model of colorectal liver metastases.BMC Cancer. 10: 82.6. Liao, D.et al.(2009) Cancer Associated Fibroblasts Promote Tumor Growth and Metastasis by Modulating the Tumor Immune Microenvironment in a 4T1 Murine Breast Cancer ModelPLoS One. 4: e7965.7. Moos, M.P.et al.(2005) The lamina adventitia is the major site of immune cell accumulation in standard chow-fed apolipoprotein E-deficient mice.Arterioscler Thromb Vasc Biol. 25: 2386-91.8. Stevenson, P.G.et al.(2002) Uncoupling of virus-induced inflammation and anti-viral immunity in the brain parenchyma.J Gen Virol. 83: 1735-43.9. Wang, X.et al.(2011) Quercetin and Bornyl Acetate Regulate T-Lymphocyte Subsets and INF-γ/IL-4 Ratio In Utero in Pregnant Mice.Evid Based Complement Alternat Med. 2011: 745262.10. Zeis, M.et al.(2002) Idiotype protein-pulsed dendritic cells produce strong anti-myeloma effects after syngeneic stem cell transplantation in mice.Bone Marrow Transplant. 29: 213-21.

技术参数

产品应用 Flow

产品类型 单克隆抗体

推荐用于 Flow

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