Mouse anti Human CD254, clone C01-2D2 BIO-RAD MCA5971GA Mouse anti Human CD254, clone C01-2D2-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

Mouse anti Human CD254, clone C01-2D2 BIO-RAD MCA5971GA Mouse anti Human CD254, clone C01-2D2

2024-10-29

Mouse anti Human CD254, clone C01-2D2

货号：MCA5971GA

规格：0.1 mg

市场价格：2550

产品类型：免疫组化一抗

品牌：Bio-Rad

抗原：CD254

物种：人

宿主：小鼠

抗体亚型：IgG2b

克隆号：C01-2D2

荧光染料：Purified

产品介绍
Mouse anti Human CD254, clone C01-2D2recognizes CD254 also known as RANKL and TNFSF11. CD254 is a ~20 kDa glycoprotein, a member of the tumour necrosis factor (TNF) superfamily. CD254 is a ligand for the receptor activator of NFκB (RANK) and this interaction plays a role in osteoclastogenesis and bone resorption (Roodman 1999).CD254 is highly expressed by T lymphocytes and osteoblastic cells and it has been shown that the CD254/RANK interaction also plays a vital role in several immune related processes. These include lymph node and lymphocyte development (Kong et al. 1999), dendritic cell survival (Wong et al. 1997) and T-cell activation (Anderson et al. 1997). CD254 is also involved in apoptosis, through activation of the anti-apoptotic kinase AKT/PKB and the mTOR/S6K signalling pathway.
产品详情
Target Species	Human
Product Form	Purified IgG - liquid
Preparation	Purified IgG prepared by affinity chromatography on Protein G from ascites
Buffer Solution	Phosphate buffered saline
Preservative Stabilisers	<0.1% Sodium Azide (NaN3)
Immunogen	E. coliderived recombinant protein corresponding to aa 143-317 of human CD254
Fusion Partners	Spleen cells from immunised BALB/c mice were fused with cells of the mouse SP2/0 myeloma cell line
Approx. Protein Concentrations	IgG concentration 1.0 mg/ml
Regulatory	For research purposes only
Guarantee	12 months from date of despatch
存储条件
Store at -20℃ only.This product should be stored undiluted.Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
应用
Application Name	Verified	Min Dilution	Max Dilution
ELISA	√
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
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文献
1.Roodman, G.D. (1996) Advances in bone biology: the osteoclast.Endocr Rev. 17 (4): 308-32.2.Kong, Y.Y.et al.(1999) OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis.Nature. 397 (6717): 315-23.3.Anderson, D.M.et al.(1997) A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function.Nature. 390 (6656): 175-9.4.Wong, B.R.et al.(1997) TRANCE (tumor necrosis factor [TNF]-related activation-induced cytokine), a new TNF family member predominantly expressed in T cells, is a dendritic cell-specific survival factor.J Exp Med. 186 (12): 2075-80.

技术参数

产品应用 Elisa

产品类型 Monoclonal Antibody

推荐用于 Elisa

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Mouse anti Human CD254, clone C01-2D2 BIO-RAD MCA5971GA Mouse anti Human CD254, clone C01-2D2

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