Mouse anti Human CD42a antibody, clone FMC-25 BIO-RAD MCA594GA Mouse anti Human CD42a antibody, clone FMC-25-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

Mouse anti Human CD42a antibody, clone FMC-25 BIO-RAD MCA594GA Mouse anti Human CD42a antibody, clone FMC-25

2024-10-29

Mouse anti Human CD42a antibody, clone FMC-25

货号：MCA594GA,MCA594

规格：0.1 mg,0.25 mg

市场价格：2567,3863

产品类型：流式抗体

品牌：Bio-Rad

抗原：CD42a

物种：人

宿主：小鼠

抗体亚型：IgG1

克隆号：FMC-25

荧光染料：Purified

产品介绍
Mouse anti Human CD42a antibody, clone FMC-25recognizes human CD42a, also known as Platelet glycoprotein IX, Glycoprotein 9 or GP-IX. CD42a is a 177 amino acid, ~20kDa type I single pass transmembrane glycoprotein containing a singleleucine-rich repeat containing N-terminaldomain and a singleleucine-rich repeat containing C-terminaldomain.CD42a is expressed by platelets and megakaryocytes and forms a covalent complex with CD42c (GP-1b-beta), CD42b (GP-1b-alpha) and CD42d (platelet glycoprotein V) to create the platelet surface receptor for von Willebrand factor. Incubation of the intact von Willebrand receptor complex with clone FMC-25 does not appear to inhibit binding of von Willebrand factor to the receptor (Yanet al.2011). Defects in the GP1BB gene encoding human CD42a can lead to the inherited bleeding disorder Bernard-Soulier syndrome (Diz-Küçükkaya 2013), characterized by prolonged bleeding times, thrombocytopenia and the appearance of giant platelets in the circulation (Johnset al.2014).Mouse anti human CD42a antibody, clone FMC-25 has been successfully used as a capture reagent for platelet-autoantibody complexes in the sera of patients presenting thrombocytopenia associated with antiphospholipid syndrome (Godeauet al.1997).
产品详情
Target Species	Human
Product Form	Purified IgG - liquid
Preparation	Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant
Buffer Solution	Phosphate buffered saline
Preservative Stabilisers	0.09% Sodium Azide (NaN3)
Immunogen	Peripheral blood mononuclear cells.
Approx. Protein Concentrations	Pack Size: 0.1 mgIgG concentration 1.0mg/mlPack Size: 0.25 mgIgG concentration 1.0 mg/ml
Regulatory	For research purposes only
Guarantee	12 months from date of despatch
存储条件
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
应用
Application Name	Verified	Min Dilution	Max Dilution
Flow Cytometry	√	1/50
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
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文献
1.Zola, H.et al.(1984) Monoclonal antibodies against antigens of the human platelet surface: preparation and properties.Pathology. 16 (1): 73-8.2.Berndt, M.C.et al.(1985) Molecular characterization of quinine/quinidine drug-dependent antibody platelet interaction using monoclonal antibodies.Blood. 66 (6): 1292-301.3.Berndt, M.C.et al.(1985) Purification and preliminary characterization of the glycoprotein Ib complex in the human platelet membrane.Eur J Biochem. 151 (3): 637-49.4.Berndt, M.C.et al.(1983) Additional glycoprotein defects in Bernard-Soulier's syndrome: confirmation of genetic basis by parental analysis.Blood. 62 (4): 800-7.

技术参数

产品应用 Flow

产品类型 Monoclonal Antibody

推荐用于 Flow

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Mouse anti Human CD42a antibody, clone FMC-25 BIO-RAD MCA594GA Mouse anti Human CD42a antibody, clone FMC-25

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